Preventing the Onset and Progression of Neurodegenerative DiseasesCaviarlieri | Published August 4, 2021
Our brain is an extremely complex organ with vast numbers of pathways that allow us to do the amazing things that we do. The brain is made up of billions of cells that we depend on every second in order for us to function on a daily basis.
Neurons are some of the most important nerve cells in our brain. Neurons communicate with each other to perform every function of the brain, whether it involves moving around, thinking about topics learned in school, talking to friends, or remembering the list of things we want to buy from the grocery store. Because of the brain’s complexity, brain disorders can arise from very small miscommunications between cells.
Although there are many diseases and illnesses that can affect the brain, the most complicated of these diseases are called Neurodegenerative Diseases.
Neurodegenerative diseases or degenerative brain diseases occur when our nervous system cells (neurons) in the brain and the spinal cord begin to deteriorate. Changes in these cells cause them to function abnormally and eventually result in the cells’ demise. These diseases are a great example of the devastating effects of miscommunications between brain cells and they can influence an individual’s movement, speech, memory, intelligence, and much more. As neurons deteriorate, an individual may first experience relatively mild symptoms — problems with coordination or remembering names. But as huge numbers of neurons die, the symptoms progressively worsen. In some cases, patients lose the ability to walk independently, think clearly, or generally function in the world. Ultimately, many of these diseases are fatal.
According to a report by Harvard Neuro Discovery Centre, by 2030, it is estimated that more than 12 million Americans will suffer from neurodegenerative diseases.
Degenerative brain diseases are progressive, meaning that the condition worsens over time as greater numbers of neurons in the brain will inevitably die. Due to the complexity of such diseases, the causes remain a mystery.
Neurodegenerative Disorders Include:
- Alzheimer’s disease and other memory disorders
- Huntington’s disease
- Parkinson’s disease
- Motor neuron disease
- Multiple system atrophy
Neurodegenerative Diseases and their Adverse Effects
Parkinson’s disease is a progressive disorder that is caused by degeneration of nerve cells in the part of the brain called the substantia nigra, which controls movement. These nerve cells die or become impaired, losing the ability to produce an important chemical called dopamine. Studies have shown that symptoms of Parkinson’s develop in patients with an 80 percent or greater loss of dopamine-producing cells in the substantia nigra.
Normally, dopamine operates in a delicate balance with other neurotransmitters to help coordinate the millions of nerve and muscle cells involved in movement. Without enough dopamine, this balance is disrupted, resulting in tremor (trembling in the hands, arms, legs and jaw); rigidity (stiffness of the limbs); slowness of movement; and impaired balance and coordination – the hallmark symptoms of Parkinson’s.
Unlike Parkinson’s Disease, Huntington’s Disease is a genetic disease that can be passed on from parent to child and affects the basal ganglia, leading to problems with movement. This means that if either parent has the disease, the children are also very likely to have the illness.
Huntington’s Disease is a result of abnormal protein build-up in the brain, which results in neuronal death, causing the movement disorder. Mainly, individuals with this disease will show excessive movement, movement that is generally unwanted and unnecessary. For example, they often have constant vibrating limbs, something that is out of their control. As the disease progresses, people with Huntington’s will find it increasingly hard to move the way they want to move.
It is estimated that by 2050 China will have a population of demented people equal to the current population of California (37 million).
As of a 2021 report, the Alzheimer’s disease Association estimates that the number of Americans with Alzheimer’s disease could be as many as 6.2 million.
Two common types of dementia are Alzheimer’s Disease and Lewy body dementia. Every type of dementia is a result of neurodegeneration (shrinking of the brain). Shrinking is caused by a lot of neuronal death occurring throughout the brain. Because of the large number of neurons dying, people with dementia not only start losing their memories, but they eventually lose their ability to move, communicate, and even think properly.
What causes Brain Degeneration?
The process that allows our brains to learn and generate new memories also leads to degeneration as we age, according to a new study by researchers at MIT.
Each time we learn something new, our brain cells break their DNA, creating damage that the neurons must immediately repair, according to Li-Huei Tsai, the Picower Professor of Neuroscience and director of the Picower Institute for Learning and Memory at MIT.
Cells physiologically break their DNA to allow certain important genes to be expressed. In the case of neurons, they need to break their DNA to enable the expression of early response genes, which ultimately pave the way for the transcriptional program that supports learning and memory, and many other behaviours.
As we age, our cells’ ability to repair this DNA damage weakens, leading to degeneration. When we are young, our brains create DNA breaks as we learn new things, but our cells are absolutely on top of this and can quickly repair the damage to maintain the functionality of the system. But as we age and with some genetic conditions, the efficiency of the DNA repair system is compromised, leading to the accumulation of damage, and this could be very detrimental.
Causes of Neurodegenerative Diseases
The risk of being affected by a neurodegenerative disease increases dramatically with age. More Americans are living longer and this means more people may be affected by neurodegenerative diseases in the coming decades. This situation creates a critical need to improve our understanding of what causes neurodegenerative diseases and develop new approaches for treatment and prevention.
Scientists recognize that the combination of a person’s genes and the environment contributes to their risk of developing a neurodegenerative disease. That is, a person might have a gene that makes them more susceptible to a certain neurodegenerative disease. But whether, when, and how severely the person is affected depends on environmental exposures throughout his life.
Oxidative stress has also been linked to several neurological diseases (i.e., Parkinson’s disease, Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis, depression, and memory loss) In addition, an accumulation of misfolded protein in the aging brain results in oxidative and inflammatory damage, which in turn leads to energy failure and synaptic dysfunction.
Can We Cure Neurodegenerative Diseases?
Although treatments may help relieve some of the physical or mental symptoms associated with neurodegenerative diseases, there is currently no way to slow disease progression and no known cures. While drugs and medications can help mitigate the symptoms, they do not stop the damage of brain degeneration and the death of neurons.
Reducing and Controlling Oxidative Stress for Brain Health
In a scientific report titled “Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options” which was published in 2009, it was reported that an imbalanced defense mechanism of antioxidants, overproduction or incorporation of free radicals from the environment to living system leads to neuro-degeneration.
Though, oxygen is imperative for life, imbalanced metabolism and excess reactive oxygen species (ROS) or free radicals generation lead into a range of disorders such as Alzheimer’s disease, Parkinson’s disease, aging and many other neural disorders.
Toxicity of free radicals contributes to proteins and DNA injury, inflammation, tissue damage and subsequent cellular apoptosis. Antioxidants are now being looked upon as persuasive therapeutically against neuronal loss, as they have the capability to combat by neutralizing free radicals to prevent oxidative stress and therefore preventing neuronal degeneration in a post-oxidative stress scenario.
Caviarlieri – A Swiss Caviar Cellular Therapy Supplement
“Delay the Onset and Progression of Brain Degenerative Disease”
Caviarlieri, a potent Caviar Supplement with potent antioxidants, is scientifically and synergistically developed to stimulate and trigger our own body system to heal, repair and renew our cells versus damaged cells. By providing bio active nutrition at the cellular level, Caviarlieri helps to accelerate protein synthesis and cellular repair.
A peer reviewed in vitro study of Caviarlieri published in PubMed and Europe PMC demonstrates that Caviarlieri, a Swiss Caviar supplement facilitates the differentiation of the whole set of brain cells (neurons, astrocytes and oligodendrocytes). The observed reciprocal response between neuronal and glial populations suggest that Caviarlieri can potentially affect a neuronal lineage of the neural progenitor cells, and it therefore has the ability to generate both neuronal and glial cells. Thus, Caviarlieri can effectively protect degeneration in some integral parts of the brain, specifically the Hippocampus and may be able to stimulate neurogenesis in the mature brain.
EFFECTIVE PROPERTIES OF A STURGEON-BASED BIOACTIVE COMPOUND (Caviarlieri) ON STRESS-INDUCED HIPPOCAMPAL DEGENERATION AND ON IN VITRO NEUROGENESIS
F Marotta, DH Chui, H Yadav, A Lorenzetti, Celep G, S Jain, A Bomba, A Polimeni, K Zhong, F Allegri
Journal of Biological Regulators & Homeostatic Agents
Volume 26 Number 3, July-September 2012
The aim of this study was to test the activity of a marine bioactive compound containing high-purity caviar-derived DNA, collagen elastin and protein extracts from sturgeon to exert neuroprotective properties in an experimental setting while also being potential triggers of neurogenesis in a separate in vitro study. Supplementation with high-DHA mixture and Caviar DNA Extract (LD-1227) in Caviarlieri was applied for 30 days to stress model rats. Both supplementations significantly mitigated the histological brain damage when analysing hippocampal subregions and corticosterone level. However, Caviar DNA Extract (LD-1227 ) was most significantly efficient in preventing SOD, Catalase and ascorbic acid decrease in brain tissue as compared to DHA.
Rats were subjected to immobilization stress and given orally (or mixed in their regular diet) as follows:
- Group A- regular chow food
- Group B- natural fish oil rich in DHA (10 mg) mixed into regular food
- C- Caviar DNA Extract (LD-1227) 10 mg given orally with their regular diet
Group A demonstrated neuron cell degeneration in CA1, CA2, Ca4 and also in Dg of hippocampus compared to the control (healthy) group. Nerve cell degeneration was observed in almost all 6 layers of the hippocampus. It is evident that in Group B (DHA )and Group C (Caviar DNA Extract), the number of degenerating cell bodies were significantly reduced and to a comparable extent. Cell bodies of all six layers of the hippocampus demonstrated normal neuronal morphology.
Results stress marker:
Corticosterone activity was significantly increased (156.6 µg/100ml) in rats after applying the stress regimen. Corticosterone level almost doubled in stressed animals and Caviar Extract (LD-1227) treatment and DHA brought about a comparable partial improvement in stress levels (p<0.01 vs stressed animals).
Ascorbic acid content in the brain tissue, which can be a preliminary marker of stress, decreased in stress treated animals (1.4 mg/100ml) as compared to healthy control (2.4 mg/100 ml of tissue; p < 0.01). After treatment with Caviar Extract (LD-1227), an increase in ascorbic acid content was observed and also reached a statistic significance level (p < 0.01). The values shown are almost close to the healthy control group.
Accordingly, the SOD activity was significantly decreased by over 33% in stressed animals as compared to control (p < 0.005), and it was restored only in the C group who were treated with Caviar Extract (p<0.05 vs B group, p<0.001 vs A group).
Catalase level in the experimental groups demonstrated a significant change as compared to control with a decrease in the A group by 40% and was restored only in C group rats treated with Caviar Extract (Ld-1227) (p<0.05 vs B group, p<0.01 vs A group).
The spontaneous MDA activity was the highest in the stress group (2.9 nmoles/ml) when compared to respective concentration of MDA in rats treated with either supplement in which the content normalized (A group vs healthy control: p <0.001) (Table 2).
Both supplements stimulated neurogenesis in vitro and neurons marker in particular but the markers such as og oligodendrocytes and glia increased only in those who took the Caviar Extract (LD-1227)-enriched medium. Taken together these data suggest that Caviar Extract (LD-1227) in Caviarlieri is able to significantly protect brain structure redox system at a higher degree than DHA.
Brain Protection Study – Caviarlieri
In another peer reviewed study published in the Journal of Clinical and Diagnostic Research, it was evident that the supplementation of Caviarlieri can lead to a significant increase in the levels of BDNF. BDNF stands for Brain-derived Neurotrophic Factor which is a protein that promotes the survival of nerve cells by playing a role in the growth, maturation, and maintenance of these cells. With the nerve cells survivability enhanced, this will potentially help prevent the occurrence of degenerative symptoms. BDNF also generates therapeutic effects for metabolic and neurological diseases.
A Double-Blind, Rct Testing Beneficial Modulation of Bdnf in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection
The aim of this prospective study was to see whether LD-1227, a quality-controlled marine nutraceuticals shown to protect experimental stress-induced hippocampal degeneration, could beneficially modulate BDNF, as measured in the serum, in otherwise healthy but work-stressed individuals.
It appears that there is a beneficial effects of LD-1227 on measures of psychological well-being and related anxiety in healthy and healthy-stressed individuals as well as salivary stress markers and concomitant increase of serum level of BDNF. This may suggest longer term studies in view of a neuroprotective strategy against stress-induced neurodegeneration.
According to the study, we cannot rule out that Caviarlieri may contain other smaller unsaturated fatty acids, structural phospholipids and neurotransmitter precursors, which may to pass through blood-brain barrier and which remain to be defined by further ongoing studies.
Key Ingredients of Caviarlieri
Caviarlieri – Caviar Swiss Cell Therapy Supplement is synergistically formulated the following potent key bioactive ingredients:
Caviar Cellular DNA Extracts and Marine Peptides
One of the key ingredients of Caviarlieri is the Caviar Cellular DNA extract with Marine peptides, which can help in the rejuvenation and revitalization of cells.
These bio marine compounds have also been found to have a positive effect on basic mechanisms that affect key inflammatory molecules involved in metabolic syndrome.
In addition, these extracts have strong antioxidant properties which can potentially help to reduce oxidative stress in the brain.
Marine Collagen and Elastin Plus
Collagen is a protein that forms connective tissues throughout the body and it has 20 amino acids/ peptides that aid in brain and memory support. It is known that aging slows down the production of collagen. Marine collagen in Caviarlieri has a relatively high percentage of natural peptides such as Glycine and others which contribute to healthy neurological and cognitive function. Other benefits of marine collagen include improvement in sleep quality, better focus and reduction in anxiety levels.
Collagen studies are also underway for its capacity to protect brain cells against Amyloid-Beta proteins which are widely thought to cause Alzheimer.
Mitochondria is a part of the cell that generates energy. For brain cells, it is the main energy-generator. With aging, mitochondrial function decreases and its total dysfunction can lead to death of the brain cells which result to cognitive decline in diseases like Alzheimer’s and Parkinson’s.
The brain is very vulnerable to oxidative damage because of its high demand for oxygen and high fatty acid content. Co-enzyme q10 reduces the proliferation of these harmful compounds to slow down progression of neurodegenerative diseases. Antioxidant stores in the body also decline with age. Co-enzyme Q10 has the potential to improve brain function due to established benefits on mitochondrial function, vascular function and oxidative stress. All of which contribute largely to overall brain health.
Selenium is a trace mineral and may not be deemed as necessary to the body as many other minerals and studies show that Selenium can potentially contribute to our brain health and even help alleviate depression.
One journal states “Selenium is an essential trace element that is vital for the proper functioning of several selenoproteins involved in antioxidant defense within the brain and nervous system”.
Selenium has antioxidant properties that help supplement decreasing antioxidant levels in aging as well as reducing free radicals that have negative effects to the brain. Selenium serum level is also associated with decreased cognitive function and it was evident that patients suffering from Alzheimer’s have lower blood levels of selenium.
The combination of these potent ingredients and their therapeutic effects make Caviarlieri a necessity for brain protection and for delaying the progression of age related brain degenerative diseases.
Caviarlieri is NOT A DRUG but a potent oral food supplement approved by the Swiss Public Health Authority. Unlike drugs or medications, there are no side effects for long term use. Caviarlieri is on Cologne List®. The Cologne List® lists dietary supplements with a minimized risk of doping, which have been tested for selected anabolic steroids and stimulants by an independent scientific laboratory, which is one of the world’s leading labs in the field of analytical testing for banned substances in nutritional supplements.