According to a recently published article in the Journal of Cancer & Metastasis Reviews, severe COVID-19 illness can result in excessive inflammation throughout the body, including the lungs, heart and brain. This study examined the human body’s robust inflammatory response to the SARS-CoV-2 virus, which is now recognized as a hallmark symptom.

According to this well researched article, controlling the body’s inflammatory to SARS-CoV-2 will likely be as important as antiviral therapies or a potential vaccine. Individual mediators in our body—called cytokines—cause inflammation in response to tissue injury or infection. Mediators are a substance or a structure that mediates a specific response in our bodily tissue.

Rather than blocking cytokines, virus-induced inflammation can be controlled or managed by broadly activating the body’s natural healing system to control inflammation.

Medical experts are recognizing the importance of controlling this robust inflammatory response in COVID-19 (coronavirus) infection in order to reduce associated organ damage and mortality as a consequence of the disease. Finding new ways to dampen the body’s inflammatory response to COVID-19 will likely be as important as finding effective antiviral therapies to control COVID-19 infection and reduce life-threatening organ damage.

The research study found that:

• one hallmark of SARS-CoV-2 infection is a cytokine storm, which is a drastic increase in immune cell production of cytokines;
• SARS-CoV-2 causes unchecked inflammation that can cause extensive organ damage, such as lung failure;
• current therapeutic strategies in COVID-19 focus on inhibiting a single pro-inflammatory cytokine rather than broadly inhibiting the body’s inflammatory response;
• lipid mediators derived from omega-3 fatty acids serve as the body’s natural “stop” signals to inflammation.

Increasing levels of these lipid mediators in the body could be a new therapeutic approach to preventing life-threatening inflammation caused by SARS-CoV-2.

“What is exciting for us is that these lipid mediators that ‘turn off,’ or resolve inflammation are already in clinical trials for other inflammation-driven diseases, such as eye disease, periodontal disease and pain,” said Dipak Panigrahy, an assistant professor of pathology in Beth Israel Deaconess Medical Center. “The mediators can quickly be applied to turn off inflammation in COVID-19 patients.”

Dipak Panigrahy, an assistant professor of pathology in Beth Israel Deaconess Medical Center

In addition, experts claim that these compounds have been found to be non-toxic and non-immunosuppressive in ongoing clinical trials for other inflammatory diseases, making them even more promising candidates for rapid clinical translation.

Caviarlieri – Controlling and Averting Inflammation Caused by COVID-19

Caviarlieri is a Swiss Caviar Food Supplement formulated with the finest Caviar Cellular Extracts and marine peptides and highly polymerized collagen, which have strong anti-inflammatory properties.

This Swiss Caviar Oral Supplement contains high levels of essential fatty acids (EPA/DHA) and therefore acts as a lipid mediator, activating cellular repair and renewal to reduce and turn off inflammation at the molecular level.

Caviarlieri is scientifically proven to help reduce the Tumour Necrosis Factor Alpha which is an important inflammatory biomarker for metabolic syndrome conditions. In addition, Caviarlieri can also reduce the C-reactive protein (CRP), a blood test marker for inflammation in the body. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation.

There are also several current and ongoing studies which indicate that Caviarlieri triggers the epigenetic mechanisms of the cells to activate gene expression for inflammation reduction which will help alleviate the onset of any of the risks associated with the diseases as a consequence of metabolic syndrome.

Therefore, taking Caviarlieri – the Swiss Caviar Cellular Therapy Supplement may potentially be a new therapeutic approach to preventing life-threatening inflammation caused by SARS-CoV-2. The peer reviewed scientific studies on Caviarlieri have found that it has potent anti-inflammatory properties from a biochemical and at the molecular level and it proves that it can potentially help avert inflammation caused by COVID-19 (coronavirus).

Note: Metabolic syndrome is a cluster of conditions such as high blood pressure, high blood sugar, unhealthy cholesterol levels, excess abdominal fat that increases your risk of heart disease, stroke and type 2 diabetes.

A. Strong Anti-Inflammatory Properties of Caviarlieri

1. Published in Peer Reviewed Journal – Acta Bio Medical / Official Journal of the Society of Medicine and Natural Sciences of Parma Vol 84-53-60/2013

A sturgeon-derived bioactive compound beneficially modulates nuclear receptors controlling metabolic functions in patients with metabolic syndrome

A. Lorenzetti, R. Catanzaro, G. Bertuccelli, N. Zerbinati, . Jain, U. Solimene, S.K. Yaduvanshi, N. Srivastava, E.Minelli, H. Yadav, C. Tomella, F.Marotta

The aim of the study was to test the possible effects of a novel sturgeon-derived compound Caviar DNA Extract (LD-1227) on inflammatory markers related to metabolic nuclear receptors in patients with metabolic syndrome. The study population consisted of 76 patients with metabolic syndrome and 30 healthy subjects who were maintained to their current treatments and randomly supplemented with A) Caviar DNA Extract (LD-1227) (n=38) or B) placebo (n=38) as compared to C) healthy controls (n=30). Caviar DNA Extract (LD-1227) or placebo (water-soluble starch) were given daily at breakfast and dinner for three months.

At the end of the study period, as compared to B group, Caviar DNA Extract LD-1227-treated patients showed a significant improvement of all parameters (hs-CRP, IL-6, TNF-alpha) tested, irrespective of the presence of diabetes. Although the metabolic syndrome remains a multifaceted condition requiring a complex approach, Caviarlieri (LD-1227) could be a potential safe therapeutic tool to be integrated into a wider treatment and preventive medicine schedule strategy.

Figure 1a. Time course change of IL-6 In patients with Metabolic Syndrome with/without diabetes: effect of treatment with Caviar DNA Extract (LD-1227). Throughout the whole study, the level of IL-6 was significantly higher in Metabolic Syndrome patients as compared to healthy controls and it was not affected by the presence of diabetes (p<0.05, fig 1). After intervention with Caviar DNA Extract (LD-122), IL-6 level decreased significantly in all Metabolic Syndrome patients (p<0.05 vs baseline and vs placebo group).

Note: Interleukin-6 is a cytokine not only involved in inflammation and infection responses but also in the regulation of metabolic, regenerative, and neural processes.

After intervention with Caviar DNA Extract (LD-1227), TNF-α level (inflammation) decreased significantly in all Metabolic Syndrome patients (p<0.05 vs baseline and vs placebo group).

The level of hs-CRP in patients with Metabolic Syndrome was significantly higher than in healthy controls (p<0.05, fig 2) and particularly in those with overt diabetes (p<0.05 vs MS patients without diabetes). After intervention with Caviar DNA Extract (LD-1227), hs-CRP significantly decreased (p<0.05 vs placebo).

Note: C-reactive protein (CRP) is a blood test marker for inflammation in the body. CRP is produced in the liver and its level is measured by testing the blood. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation. A high-sensitivity C-reactive protein (hs-CRP) test, which is more sensitive than a standard test, also can be used to evaluate your risk of developing coronary artery disease, a condition in which the arteries of your heart are narrowed. Coronary artery disease can lead to a heart attack.

Conclusion

The intervention with Caviar DNA Extract (LD-1227) has shown in human chondrocytes that this sturgeon-derived compound could effectively inhibit IL-1β-induced proliferation and inflammatory reactions via inhibited activation of the transcription factor NF-κB pathway. Caviarlieri contains collagen elastin, protein and a rich array of other smaller unsaturated fatty acids, and structural phospholipids which may exert a synergistic action on multiple mechanisms of the inflammatory cascade.

Full study on Caviarlieri’s potent anti-inflammatory properties.

2. Published in Peer Reviewed Journal – Acta Bio Medical / Official Journal of the Society of Medicine and Natural Sciences of Parma Vol 84-N1/2013

Testing a novel bioactive marine nutraceutical (Caviarlieri) on Osteoarthritis patients

Biochemistry Analysis – Blood tests

Patients in the two groups were tested for inflammatory markers like Tumour Necrosis Factor Alpha, C Reactive Protein, Interleukin 6 etc, cytokines during the 18 weeks study period after taking the Caviar DNA extract (LD-1227) versus those taking Glucosamine Chondroitin(GC)

The above data demonstrates that patients administered with Caviar DNA extract (LD-1227) have demonstrated significantly Lower Inflammation over time as compared to GC. This implies that Caviarlieri can not only help to reduce joint pain over time but more importantly also reduce chronic inflammation.

Why is Caviarlieri a Safe and Potent Option?

Caviarlieri is not a drug but a oral food supplement approved by the Swiss Public Health Authority. Unlike drugs or medications, there are no side effects for long term use. Caviarlieri is also is a listed supplement in the Cologne list, which is an integral part of Gemeinsam gegen Doping. This is initiated by the Prevention Department of the National Anti Doping Agency (NADA), and includes all top Olympic associations, all state sports associations and federations, as well as professional associations and clubs.

Manufactured using the Swiss Cold Process Extraction Technology, Cellularix, Caviarlieri comes in a soft gel form which encapsulates the Caviar bioactive nutrients and marine peptides for optimal absorption. It is important to remember that not everything we consume can be absorbed.