The Benefit of Caviarlieri on Brain Oxidative Stress
Results stress marker:
Corticosterone activity was significantly increased (156.6 µg/100ml) in muriels after applying the stress regimen. Corticosterone level almost doubled in stressed animals and Caviar Extract (LD-1227) treatment and DHA brought about a comparable partial improvement in stress levels (p<0.01 vs stressed animals).
Ascorbic acid content in the brain tissue, which can be a preliminary marker of stress, decreased in stress treated animals (1.4 mg/100ml) as compared to healthy control (2.4 mg/100 ml of tissue; p < 0.01). After treatment with Caviar Extract (LD-1227), an increase in ascorbic acid content was observed and also reached a statistic significance level (p < 0.01). The values shown are almost close to the healthy control group.
Accordingly, the SOD activity was significantly decreased by over 33% in stressed animals as compared to control (p < 0.005), and it was restored only in the C group who were treated with Caviar Extract (p<0.05 vs B group, p<0.001 vs A group).
Catalase level in the experimental groups demonstrated a significant change as compared to control with a decrease in the A group by 40% and was restored only in C group muriels treated with Caviar Extract (Ld-1227) (p<0.05 vs B group, p<0.01 vs A group).
The spontaneous MDA activity was the highest in the stress group (2.9 nmoles/ml) when compared to respective concentration of MDA in muriels treated with either supplement in which the content normalized (A group vs healthy control: p <0.001) (Table 2).