Helps Control High Blood Pressure/
Hypertension

Helps Control High Blood Pressure/
Hypertension

High blood pressure or hypertension is severely injurious to our health because it exerts undue pressure on the heart to work harder than normal in order to pump blood to our heart and into the other organs of our body. After a period of time this will cause the hardening of our arteries, a condition known as atherosclerosis. Persistent high blood pressure if left untreated can increase your risk of a number of serious and potentially life-threatening health conditions, such as heart disease, heart failure, heart attacks, strokes, kidney disease etc.

Nearly half of the adults in the United States (108 million, or 45% of the population) have hypertension. Hypertension is defined as a condition when your systolic blood pressure is above 130 mmHg or your diastolic blood pressure is below 80 mmHg. It is estimated that only about 1 in 4 adults (24%) with hypertension have their condition under control.

Most people who have high blood pressure do not display symptoms which gives an early warning of their condition.

Why Caviarlieri

Caviarlieri is scientifically proven to help reduce the inflammatory infiltration of the intima, which is the innermost part of a blood vessel. Arteries are the blood vessels that deliver oxygen-rich blood from the heart to the tissues of the body. High blood pressure patients usually have "thickened intima" or hardening of the blood vessels.

A study on Caviarlieri published in Europe PMC with the title "Protective Effect of a Fish Egg Homogenate Marine Compound on Arterial Ultrastructure in Spontaneous Hypertensive Rats" shows that the "thickened intima/ blood vessels" in spontaneous hypertensive rats were significantly reduced when treated with Caviar DNA Extracts- LD 1227. This will potentially reduce the risks of cardiovascular diseases.

The same study also demonstrates significant reduction in endothelial damage and dysfunction in spontaneous hypertensive rats treated Caviar DNA Extracts- LD 1227. In endothelial dysfunction, the vasodilation is impaired, and the arteries begin to lack the ability to dilate properly. This dysfunction can be a significant predictor of coronary artery disease and atherosclerosis, a chronic disease which can cause a stroke or heart attack.

Therefore, the results of the study suggests that Caviarlieri has "arterial protective properties" and may potentially help prevent the onset and delay the progression of cardiovascular diseases.

Protective Effect of a Fish Egg Homogenate Marine Compound on Arterial Ultrastructure in Spontaneous Hypertensive Rats

1. Published in Peer Reviewed Journal – Rejuvenation Research Volume 17 Number 2, April 2014

Nicola Zerbinati,1 Francesco Marotta,2 Ravinder Nagpal,3,4 Birbal Singh,5 Dheeraj Mohania,6 Michele Milazzo,7 Angelo Italia,7 Claudio Tomella,2 and Roberto Catanzaro7

It has been reported that lipid peroxidation may be partly responsible for the detrimental effects of changes in arterial structure caused by hypertension. This study assessed the effect of a sturgeon eggs–based nutraceutical Caviar Cellular DNA Extract (LD-1227 – Caviarlieri) as compared to EPA/DHA on the ultrastructure of spontaneously hypertensive rat (SHR) aortas. The aorta is the main and largest artery in the human body. Sixty SHR were randomly divided into three groups that were fed (1) rat chow, (2) rat chow plus 10 mg of EPA/DHA, or (3) rat chow plus 10 mg of LD-1227, for 18 weeks. Afterward, the aortas of these rats were used for blind measurements of the thickened intima area and examination by electron microscopy. Control SHR showed an expanded subendothelial space and leukocyte infiltration of the intima that were reduced in LD-1227–fed rats ( p < 0.05) and less in EPA/DHA group.

Transmission electron microscopy showed endothelial alteration with severe subcellular injury and, unlike the EPA/DHA-group, LD-1227–treated rats displayed a significant reduction in endothelial alteration with severe subcellular injury ( p < 0.05). These data suggest that LD-1227 has stronger arterial protective properties and deserves further investigation for use for a preventive medicine strategy.

Figure.1 Light microscopy and electron microscopy analysis of arterial structure in spontaneously hypertensive rats (SHR): Effect of LD-1227 (Thickened Intima)

It is evident the "thickened intima/blood vessels" were significantly reduced in rats that were treated with Caviar DNA Extracts- LD 1227.

Measurements: (4110 µm² vs. 5530 µm² , p = 0.05) for rats treated with 10 mg of DHA. Caviar DNA Extract is more effective in reducing hypertension than DHA.

Thickened Intima of rats that are not treated with DHA or Caviar DNA Extracts.

Measurement : 7147 µm²

Thickened Intima of rats that are treated with DHA showed reduction with DHA even though it is not as effective Caviar DNA Extract.

Measurement :5530 µm² vs 7147 µm² non treated rats p = 0.05)

Figure. 2 Transmission electron microscopy analysis of arterial structure in spontaneously hypertensive rats (SHR): Effect of LD-1227

It is evident that the rats treated with Caviar DNA Extracts- LD 1227 displayed a significant reduction in structural alteration of endothelial cells with severe subcellular injury(atypical mitochondria of smooth muscle cells, such as swollen and vacuolated mitochondria, and several vacuoles and electron-lucent chromatin).

SHR showed an increase in the density and frequency of occurrences of cytoplasmic vacuoles and cytoplasmic processes of endothelial cells, with longer and more slender cytoplasmic processes.

Unlike the Caviar DNA Extract treated rats, in the EPA/DHA-group of rats , there is no apparent reduction of structural alteration of endothelial cells with severe subcellular injury.

Therefore, DHA is less effective than Caviar DNA Extract .

Conclusive Summary

Hypertension represents a main risk factor of cardiovascular diseases which is linked with endothelial dysfunction. Structural abnormalities of endothelium in vessels observed in hypertensive animals indicated their likely contribution to the development or maintenance of high blood pressure. Hypertension is associated with structural changes in blood vessels known as ‘‘vascular remodelling’’ that include dynamic structural changes involving cell growth, migration, phenotypic changes, and extracellular matrix synthesis and degradation. Effects of LD-1227 on the expression of angiotensin-converting enzyme 2, mitogen-activated protein kinase (MAPK) signalling, and peroxisome proliferator activated receptor-c in aortas of SHR are evident, and preliminary in-house data show a significant beneficial modulation exerted by this marine nutraceutical.

In conclusion, these preliminary data suggest that Caviar DNA Extract, LD-1227 has stronger arterial protective properties than EPA/DHA and further studies are being done to evaluate Caviarlieri for a preventive cardiovascular protective medical strategy against hypertension.

Other Evidence-Based Benefits of Caviarlieri

Substantial Reduction in Joint Pain

Caviarlieri has strong anti-inflammatory properties that can help alleviate and reduce chronic joint pain significantly. Unlike painkillers or opioids which have adverse side effects, Caviarlieri is an excellent nutritional supplement which has no side effects and is a palliative for chronic pain management.

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Improves Sexual Performance

Oxidative stress is a common pathology seen in approximately half of all infertile men. Caviarlieri can help reduce oxidative stress and cellular damage to stimulate increase in sperm count and sperm viability.

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Improves Mental Health & Sleep Quality

Clinical studies have shown that marine peptides in Caviarlieri can effectively improve your mental health, mental fatigue and improve the quality of your sleep.