For those of us who had hoped that 2021 will be the year that will put the pandemic in the past tense, it was a harsh reminder that it is still very much present and prevalent. Rather than developing plans to return to the ‘normal’ life we knew before the pandemic, we must come to terms with the fact that SARS-CoV-2 is here to stay.

The emergence of the Omicron variant last November highlighted the ongoing challenges of life with COVID-19 . Omicron is more infectious than any previous COVID variants and IT evades the immunity provided by both prior infection (with was supposed to provide natural immunity) and vaccination for even up to 3 doses. These factors, combined with limited behaviour change from the pandemic-weary populations—and the twin accelerants of transmission, holiday travel and gatherings—meant that Omicron has moved through the population with remarkable speed. Fortunately, the early evidence indicates that Omicron is, on average, less severe than Delta.

With Omicron as the dominant variant, the pandemic phase will feel like it is over for more and more people, though certainly not all.

The Big Unknown – New Variants and the Duration of Protection

By and large, the six-month future outlook globally is brighter than at any time than in the past two years. But several uncertainties could still emerge and temper the optimism, starting with the duration of the immunity. Evidence suggests that both natural and vaccine-induced immunity weakens over time, particularly against infection. So, as we consider future variants, two critical questions remain about the duration of protection: how significantly will immunity wane and henceforth provides little or no protection against future infection ? And will the booster uptake continue to slow the spread in each subsequent round of boosting?

What is Natural Immunity?

Natural immunity is the antibody protection your body creates against a germ once you’ve been infected with it. Natural immunity varies according to the person and the germ.

It is a known fact that having had COVID-19 does not make one immune to Sars-CoV-2 forever. The waning of protection after infection has been well documented in previous waves of the virus. And while most reports to date suggest that, in general, COVID-19 reinfections tend to be milder, even a less severe variant like Omicron still carries with it a risk of severe illness.

New studies also show that natural immunity to the coronavirus weakens over time, and does so faster than the immunity provided by COVID-19 vaccination.

What is Vaccine-Induced Immunity for COVID-19?

Vaccine-induced immunity is what we get by being fully vaccinated with an approved or authorized COVID-19 vaccine. Research indicates that the protection from the vaccines may wane over time so boosters are now authorized for certain populations. These boosters can extend the powerful protection offered by the COVID-19 vaccines.

Research on Natural Immunity for COVID-19, COVID Vaccine and the Combination:

Which one offers stronger protection and for how long?

Johns Hopkins has conducted a large study on natural immunity that shows antibody levels against COVID-19 coronavirus stay higher for a longer time in people who were infected by the virus and then were fully vaccinated with COVID-19 vaccines compared with those who only got immunized.

In another study, published June 15 2022 in the New England Journal of Medicine, the researchers at Weill Cornell Medicine—Qatar analysed the omicron wave in Qatar last winter, comparing prior infections, vaccine immunity and combinations thereof among more than 100,000 omicron-infected and non-infected individuals.

The analysis showed, as expected, that full vaccination plus a booster dose, atop natural immunity due to infection by an earlier variant, was associated with the strongest protection from omicron infection. However, vaccine immunity against new infection appeared to weaken rapidly, whereas people with a prior-variant infection were moderately protected from omicron with little decline in protection even a year after their prior infection.

How to Develop Sustainable Immunity via Epigenetics?

Epigenetics is the study of how our lifestyle behaviours and environment can cause changes that affect the way our genes work. Environmental factors include sleep, nutrition, toxins, etc. can influence what genes in our body get turned on or off. Excitingly, this means we have the ability to strengthen and develop sustainable immunity by modifying our lifestyle, nutritional habits and behaviour.

Epigenetics has nothing to do with our inherent DNA genes. Unlike genetic changes, epigenetic changes are reversible and do not change our DNA sequence, but they can change how our body reads a DNA sequence and the influence the level of our genetic activity for optimal health. With the optimal genetic expressions, our body can produce the necessary proteins to accelerate cellular repair and renewal against damaged cells and keep us in good health.

Chronic Inflammation and Our Immune System

Inflammation is a natural process of healing . It is necessary for fighting infections and preparing our damaged tissues for healing. But if this process gets out of control, it can lead to several chronic diseases.

A leading cause of death in the developed world, coronary heart disease, has an inflammatory component. Chronic inflammation has also been identified in several cancers, as well as type II diabetes, inflammatory bowel disease, obesity, and Alzheimer’s disease.

Inflammation is a vital feature of our immune system. Without it, our body has no mechanism to prevent and fight infection. However when inflammation turns chronic, our immune response becomes dysfunctional and this can persist for decades, resulting in an overall weakened immune system.

Immune Modulation is Vital for Sustainable Immunity

When it comes to our immune system’s resilience and sustainability, what is crucial is having the appropriate response. Our immune response must not be underactive, neither should it over reactive. This means having a big enough response when stimulated by something foreign, like a virus, but also having no response and remaining passive to things that don’t pose a threat, like a food or pollen for example. Immune modulation is therefore vital for sustainable immunity.

An over responsive immune system leads to autoimmune diseases and is associated with chronic inflammation.

How to Develop Sustainable Immunity

Building a sustainable immune system is not equivalent to a quick fix or focusing on one-time immune “boost”. Instead, it involves cultivating daily lifestyle practices, including health diet, exercises and effective nutritional supplements that can rewire immunity and build resilience over time.

Building a sustainable immune system is not equivalent to a quick fix or focusing on one-time immune “boost”. Instead, it involves cultivating daily lifestyle practices, including health diet, exercises and effective nutritional supplements that can rewire immunity and build resilience over time.

Lifestyle improvements

Living under constant stress, even low-grade ones, that continues day in and out, causes the body to produce too much cortisol, the stress hormone. Over time, elevated cortisol lowers your resistance to fighting off infection and contributes to poor sleep and higher blood pressure.

You should protect yourself from stress and bolster your immune system with a few lifestyle changes:

• Sleep: You need seven to eight hours of quality sleep each night to fight off infection. Both exercise and stress management during the day helps with sleep at night. Your body does the most healing while you are in deep sleep, so to build immune system resiliency start improving your quality of sleep immediately.
• Breathing: Even five minutes a day of simply sitting quietly and focusing on your breath, can make a difference. Breathing can help lower your heart rate and blood pressure and reduces anxiety. Plus, it’s calming. So it’s not surprising that it also helps you sleep.
• Exercise: Exercise increases your resilience so you can fight off infection by doing both cardio and strength training.

Food, Nutrition Supplementation and Sustainable Immunity

The immune system is a complex network of cells and chemical compounds that help defend the body against infections. A number of different nutrients are involved in supporting our immune systems to work normally so that we can deal with infections.

These are outlined in the table below and you will see that you can find these immune-supporting nutrients in a wide range of foods. Having a healthy, varied diet is the best way to get all the nutrients that are important for your immune system, as well as for all the other systems of the body.

Nutrient	Role in Immune System	Food Sources
Vitamin A	Helps support T-cells (a type of white blood cell that helps identify pathogens).	Liver and cheese are dietary sources of retinol (“pre-formed” vitamin A). Dark green leafy vegetables and orange-coloured fruits and vegetables, such as carrots, sweet potato, butternut squash, cantaloupe melon and papaya, are dietary sources of carotenoids, which can be converted to vitamin A by the body.
Vitamin B6	Helps produce new immune cells, metabolise antibodies and helps immune cells to communicate.	Poultry, fish, fortified breakfast cereals, egg yolk, yeast extract, soya beans, sesame seeds and some fruit and vegetables, such as banana, avocado and green pepper.
Vitamin B12	Helps to produce new immune cells.	Meat, fish, shellfish, milk, cheese, eggs, fortified yeast extract and fortified breakfast cereals.
Vitamin C	Helps immune cells attack pathogens, helps clear away old immune cells from the site of infection and helps to maintain the skin, our external barrier to infection.	Citrus fruits, blackcurrants, strawberries, papaya, kiwi, green vegetables, peppers and tomatoes.
Copper	Helps to protect and fuel immune cells.	Bread, breakfast cereals, rice, quinoa, meat, fish and shellfish, pulses, avocado, dried fruit, nuts and seeds.
Vitamin D	Role not clear but low status is associated with reduced immune response.	Oily fish, eggs, fortified breakfast cereals, fortified spreads and fortified dairy products. We are all advised to consider taking a supplement of 10µg (micrograms) a day from October to March, and all year round if we aren't often outdoors.
Folate	Helps produce new immune cells.	Green vegetables, pulses, oranges, berries, nuts and seeds, cheeses, bread and fortified breakfast cereals.
Iron	Helps maintain the health of immune cells.	Offal, red meat, beans, pulses, nuts and seeds, fish (such as canned sardines, cockles and mussels), quinoa, wholemeal bread and dried fruits.
Selenium	Helps produce new immune cells and can help to strengthen response to infection.	Nuts and seeds (for example Brazil nuts, cashews and sunflower seeds), eggs, offal poultry, fish and shellfish.
Zinc	Helps produce new immune cells, helps develops ‘natural killer cells’ that help to fight off viruses and supports communication between immune cells.	Meat, poultry, cheese, some shellfish (including crab, cockles and mussels), nuts and seeds (in particular pumpkin seeds and pine nuts), wholegrain breakfast cereals and wholegrain and seeded breads.

The wide range of nutrients implicated in immunity suggests that a healthy, balanced and varied diet is important.

Can Nutritional Supplements help Develop Sustainable Immunity?

When it comes to vitamin and mineral supplements, although these may be flying off the shelves, we do not have strong evidence that they can prevent or treat viral infections. There is some evidence that vitamin C may reduce the duration and severity of the common cold but this is caused by a different type of virus and it is not clear whether vitamin C would have any effect on coronavirus symptoms. There has also been some research into the effect of zinc supplements, in particular zinc lozenges, on the common cold but more research is needed to determine the dosage and formulations of zinc that may have any clinical benefit. Again, we don’t know that supplements would have any benefit to protect against coronavirus.

If you are worried that your diet will not provide you with all you need, then you could consider a supplement – a multivitamin and mineral supplement may be the best approach so that you get a range of vitamins and minerals.

Try Caviarlieri, an evidence based Swiss Caviar Cell Therapy Food supplement. Backed by Scientific studies published in PubMed

Caviarlieri – Swiss Cellular Therapy Caviar Supplement

Caviarlieri is formulated with potent bioactive ingredients like Sturgeon Caviar DNA cellular extract and high quality marine peptides and marine collagen peptide which are extremely rich in amino acids and essential fatty acids known to enhance B cell activity, which could be useful for those with a compromised immune system.

Manufactured using a proprietary Swiss cold extraction technology, Cellularix, the ingredients are kept “active” so that the chemical integrity and potency of the micro nutrients are not destroyed or compromised. This will help optimize our absorption of the micro nutrients into the body and maximize the outcomes and results.

In addition, Caviarlieri is made of potent peptides which help to escort the nutrients into our cells for protein synthesis which is an important process to accelerate cellular renewal and repair versus damaged cells. If essential nutrition is provided at the cellular level, it will help maintain or strengthen the functionality of our immune system and potentially provide cellular immunity

One of the key ingredients of Caviarlieri is Marine Collagen peptides. These peptides are known to modulate 3 key factors for effective immune response – Inflammation, Tissue Damage, Oxidative Stress. For people with a compromised or dysfunctional immune system, immune modulating is vital.

Most of the fatalities related to Covid-19 are attributed to cytokines storm or hyperinflammation. A key aspect of our immune system is associated with the communication of cells which is mediated by cytokines, a broad category of enzymes or chemical messengers of the cells. Cytokines play a beneficial and detrimental role to our immune response. Apart from triggering inflammation, they are also involved in healthy tissue turnover and promote the remodeling of ECM (Extra Cellular Matrix). Extracellular matrix provides support and anchorage for the shape of the cells, regulates and determines cells dynamic and behavior including cell survival, cell proliferation, cell polarity, cell differentiation, cell adhesion, and cell migration.

The goal for a balanced, sustainable immune health system is therefore to reduce cytokines concentration without blocking its production.

Backed and Validated by Science

Clinically proven with its scientific studies which are published in world renowned peer reviewed journals and also in PubMed and Europe PMC, these studies validate the supreme rejuvenating, regenerative and anti-aging benefits of the Caviar Cellular DNA Extract and marine peptides and collagen, Co-enzyme Q10 and selenium encapsulated in Caviarlieri and demonstrate its effective therapeutic outcomes and its ability to modulate and modify disease-related processes and build and sustain immune resilience.

Genetic Expression Studies on Caviarlieri

Our genes define our potential, our limitations, and our predispositions. Our DNA sequence is inherited from our parents and this cannot be changed. However, the expression of our genes is responsive and it is influenced by epigenetics – our lifestyle, including our diet, physical exercise, sleep habits, social interactions, exposure to toxins, psychological stress, and environmental factors.

When the information stored in our DNA is converted into instructions for making proteins or other molecules, it is called gene expression. It acts as both an on/off switch to control when proteins are made and also a volume control that increases or decreases the amount of proteins made.

Scientific discoveries have shown that the expression of certain genes correlates with biological aging. Unbalanced gene activity is the root of inflammation, stress and hormonal imbalance, ultimately affecting our health-span and overall wellbeing.

Initial In-Vivo research studies (at the molecular level) on Caviarlieri for patients from age 18-83 have proven that this caviar supplement is effective in the gene expression of genes related to key anti-aging biomarkers :THEY ARE

(i) a significant reduction in the expression of the Cox2 gene which is an indication on the level of inflammation,

(ii) an increase expression of Type 1 Collagen gene – collagens are a family of proteins that strengthen and support many tissues in the body, including cartilage, bone, tendon and skin,

(iii) an increase in energy levels evident from the enhanced expression of the GABPB1 gene

Significant Reduction and Regulation of Inflammation with Caviar Cell Therapy Supplement

Caviarlieri is scientifically proven to help reduce the Tumour Necrosis Factor Alpha which is an important inflammatory biomarker for metabolic syndrome conditions. In addition, Caviarlieri can also reduce the C-reactive protein (CRP), a blood test marker for inflammation in the body. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation.

There are also several current and ongoing studies which indicate that Caviarlieri triggers the epigenetic mechanisms of the cells to activate gene expression for inflammation reduction which will help alleviate the onset of any of the risks associated with the diseases as a consequence of metabolic syndrome.

Note: Metabolic syndrome is a cluster of conditions such as high blood pressure, high blood sugar, unhealthy cholesterol levels, excess abdominal fat that increases your risk of heart disease, stroke and type 2 diabetes.

1. Published in Peer Reviewed Journal – Acta Bio Medical / Official Journal of the Society of Medicine and Natural Sciences of Parma Vol 84-53-60/2013

A sturgeon-derived bioactive compound beneficially modulates nuclear receptors controlling metabolic functions in patients with metabolic syndrome.

A. Lorenzetti, R. Catanzaro, G. Bertuccelli, N. Zerbinati, . Jain, U. Solimene, S.K. Yaduvanshi, N. Srivastava, E.Minelli, H. Yadav, C. Tomella, F.Marotta

The aim of the study was to test the possible effects of a novel sturgeon-derived compound Caviar DNA Extract (LD-1227) on inflammatory markers related to metabolic nuclear receptors in patients with metabolic syndrome. The study population consisted of 76 patients with metabolic syndrome and 30 healthy subjects who were maintained to their current treatments and randomly supplemented with A) Caviar DNA Extract (LD-1227) (n=38) or B) placebo (n=38) as compared to C) healthy controls (n=30). Caviar DNA Extract (LD-1227) or placebo (water-soluble starch) were given daily at breakfast and dinner for three months.

At the end of the study period, as compared to B group, Caviar DNA Extract LD-1227-treated patients showed a significant improvement of all parameters (hs-CRP, IL-6, TNF-alpha) tested, irrespective of the presence of diabetes. The study’s findings show that although the metabolic syndrome remains a multifaceted condition requiring a complex approach, Caviarlieri (LD-1227) could be a potential safe therapeutic tool to be integrated into a wider treatment and preventive medicine schedule strategy.

After intervention with Caviar DNA Extract (LD-1227), TNF-α level (inflammation) decreased significantly in all Metabolic Syndrome patients (p<0.05 vs baseline and vs placebo group).

The level of hs-CRP in patients with Metabolic Syndrome was significantly higher than in healthy controls (p<0.05, fig 2) and particularly in those with overt diabetes (p<0.05 vs MS patients without diabetes). After intervention with Caviar DNA Extract (LD-1227), hs-CRP significantly decreased (p<0.05 vs placebo).

Note: C-reactive protein (CRP) is a blood test marker for inflammation in the body. CRP is produced in the liver and its level is measured by testing the blood. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation.

A high-sensitivity C-reactive protein (hs-CRP) test, which is more sensitive than a standard test, also can be used to evaluate your risk of developing coronary artery disease, a condition in which the arteries of your heart are narrowed. Coronary artery disease can lead to a heart attack.

Conclusive Summary

It is evident from the above studies that Caviarlieri is a potent and effective supplement for alleviating metabolic syndrome by reducing inflammation. After administering Caviar DNA Extract (LD-1227), levels of all tested cytokines (inflammatory biomarkers) in Metabolic Syndrome patients markedly decreased whereas their levels remained unchanged in patients receiving placebo. This suggests that Caviar DNA Extract (LD-122 could provide protection for Metabolic Syndrome patients and that this protection was proportionally more evident even for patients with diabetes.

In another peer reviewed study on Caviarlieri, the intervention with Caviar DNA Extract (LD-1227) has shown in human chondrocytes that this sturgeon-derived compound with its marine collagen peptides could effectively inhibit IL-1β-induced proliferation and inflammatory reactions via inhibited activation of the transcription factor NF-κB pathway. Caviarlieri contains collagen elastin, protein and a rich array of other smaller unsaturated fatty acids, and structural phospholipids which may exert a synergistic action on multiple mechanisms of the inflammatory cascade.

Why is Caviarlieri a Safe and Potent option

Caviarlieri is not a drug but an oral food supplement approved by the Swiss Public Health Authority. Unlike drugs or medications, there are no side effects for long term use. Caviarlieri is also certified by the “Cologne List” to be free of steroids, hormones and stimulants which makes it safe for long-term use.

Caviarlieri is also backed by Science as it has several studies published in peer-reviewed journals and the multifunctional benefits are evidence based claims, like significant increase in energy levels, mood elevation, reduction in joint pain, enhancement of sleep quality, improving brain health, reduction in inflammation and many others. These are important benefits which will potentially protect us from the malefic effects of COVID-19 and help build sustainable immunity.

Build Sustainable Immunity for Long Term Health Today with Caviarlieri.

By addressing the root, instead of simply applying a band-aid to your health concerns, you’ll build a solid foundation to health and increase your resiliency. It may take a bit more effort, but it’s worth the effort to have long-lasting health.