How improved nutritional fitness can prevent Alzheimer’s disease(AD) progression?

Caviarlieri | Published September 16, 2022

Our fast-paced restless busy life comes to a halt as we start growing old. The current progressive
healthcare system is improving longevity but resulting in an uncontrollable increase in chronic lifestyle
diseases including degenerating brain diseases. One such disease dementia due to age worsens mental
capabilities and unsettles the entire old age peacefulness. Alzheimer’s disease (AD) a progressive
neurodegenerative disorder is a common type of dementia.

onset and progression of neurodegenerative diseases


Recognition of age-induced physical capability slowdown is easy but gradual steady mental decay is
mostly ignored. Hence primarily not included in the yearly full body check-up test list.


Worldwide almost 24 million people are affected by dementia with 4.6 million new cases registered
yearly. AD accounts for 50-60% of all cases, diagnosed in the population above 65 years of age.


What is Alzheimer’s disease (AD)?
It is characterized by the progressive deterioration of memory and cognitive functions.


Pathophysiology
It causes due to acetylcholine (Ach) deficiency, abnormal brain amyloid deposits and disorders of
cholinergic transmission.


A variety of factors are designated in the pathophysiology of AD, including the extracellular deposition
of b-amyloid (Aβ) plaques, accumulation of intracellular neurofibrillary tangles, oxidative neuronal
damage, and inflammatory cascades.


Symptoms
Symptoms mostly include subtle memory loss, changing emotions, and behavioural problems. In the
final stages, the affected person develops difficulty in speaking, swallowing, and walking.


High-risk groups
People with hypertension, hypercholesterolemia, heart disease, diabetes, alcohol consumption,
smoking, physical activity, and obesity. Also, individuals with advancing age, presence of
apolipoprotein E4 allele genes, family history of AD and brain injury.


Treatment
At present, there is no effectual therapy for AD and patients mostly receive only symptomatic
treatments to slow down the disease progression.


Preventive actions
Punctual prophylactic measures if introduced before the appearance of the first symptom of dementia
then AD risk can be reduced. During this crucial time the nutritional status, severalsynapses, cognition,
and neuropathological changesin the nervous system compensate for each other, which increases the
chances of staying healthy for a longer period. A proper diet, in addition to being physically and
mentally active, can be effective. It is crucial to be aware and take timely corrective action to hold up
the entire neurodegeneration.


Regular mindful eating and healthy meal pattern are important for positive mental strength but
ironically it is usually neglected and poorly prioritised. Adequate nutrition helps in healthy brain
development and protects against the onset of dementia-associated AD in later life.


Role of nutrition and appropriate nutrients
A nutritional approach to prevent and slow the progression of AD is a hopeful option. Accurate
nutritional supplementation and dietary modifications precisely influence the AD pathological
contributors such as
• Increased oxidative stress
• Mitochondrial dysfunction
• Defects in cellular energy production
• Chronic inflammatory mechanism
• Neurofibrillary degeneration


With a rightly proportionate nutrient-rich diet, essential nutritional supplementation and routine
physical activity, positive outcomes are bound to be observed in AD-risk groups.


Caviarlieari in Alzheimer’s disease


It is a unique combination of brain healthy and supportive ingredients like


Caviar cellular DNA extract and marine peptides
• Offers neuroprotective properties
• Rich source of neuroactive compounds
• Protects post-mitotic neurons from entering an unscheduled, potentially lethal cell cycle
• Significantly protects brain structure redox system
Marine collagen and elastin plus
• Counteracts neurotoxicity
• Avert collagen deficiency-associated neuro-regression
Coenzyme Q10
• Offers antioxidant benefits and neuro-protection
• Prevents oxidative stress and mitochondrial impairment
Selenium
• Stops selenium deficiency, which is mostly present in AD patients
• Positively correlated with cognitive functions


Conclusion
The appearance of unscheduled neuronal cell cycle events in AD can be arrested and hindered by
proactive regular mental health screening and suitable nutritional interventions. With a positive
lifestyle including a high intake of fruits, vegetables, fish, nuts, legumes, and cereals and a lower intake
of fried, processed, fat-rich, sugary and salty foods AD risk can be minimized.


Caviarlieari is assuredly a promising companion to slow down the progression of AD and
neurodegenerative conditions. Simultaneously AD risk groups should be made aware of the principles
of intelligent nutrition and motivated to remain self-sufficient throughout their life.


References

  1. Rocz Panstw Zakl Hig 2021;72(1):29-39
  2. International Society for Neurochemistry, J. Neurochem. (2020) 152, 493—508
  3. Eur J Neurol. 2009 September; 16(Suppl 1): 1–7
  4. Gladstone Institute for Neurological Disease and Dept of Neurology, University of California