Sustainable Immune Health – The Important of ImmunomodulationCaviarlieri | Published February 16, 2021
In a year upended by COVID-19, it seems as if our immune systems have received more attention than ever before. While many people globally have built up immunity to seasonal flu strains, COVID-19 is a new virus to which no one has immunity. To date, 105 million people were infected by Covid-19 and there are 2.3 million reported fatalities worldwide.
What no one knows yet is how the pandemic will end. This coronavirus is unprecedented in the combination of its easy transmissibility, a range of symptoms going from none at all to deadly, and the extent that it has disrupted the world. One of the keys identified to combating COVID-19 is to understand how our immune system responds to this virus and how to maintain a balanced immune system that can sustain us through this pandemic.
Our Immune System
Our immune system is a complex network of cells and proteins that works specifically to defend the body against infection, foreign invaders or harmful pollutants from the environment.
Our immune system comprises of three levels of defense mechanism that a pathogen needs to cross to develop infection inside our body. Healthy skin is the first line of defense for immune health. Our skin is the impermeable physical/mechanical barrier that protects many pathogens which can cause an infection from entering our body. But once the virus gets past these defences, then the ‘innate’ immune response” is activated. This consists of chemicals and cells which can rapidly raise the alert and begin fighting off any intruder.
When that is not enough to stop the virus invading, the adaptive immune system is activated. This involves cells and proteins, specifically antibodies which take a few days or weeks to emerge. Importantly, the adaptive immune system can only target particular pathogens. For example, a T-cell specific to Covid-19 will not respond to influenza or bacterial pathogens.
Can Boosting your Immune System Protect you from Covid-19?
Most infections will trigger adaptive immunity eventually. Therefore the concept of “boosting” one’s immune system would, presumably, involve making these responses more active, or stronger.
According to Akiko Iwasaki, an immunologist at Yale University, it is not advisable to boost your immune system. Take the symptoms of a cold – body aches, a fever, brain fog, copious amounts of snot and phlegm. Most of these problems are not actually caused by the virus itself. Instead, they’re triggered by your own body, on purpose: they are part of the innate immune response.
Inflammation is also a crucial and normal step to activate our immune responses which can lead to the healthy functioning of our tissues and cells. Pro-inflammatory symptoms and signals which are part of inflammation, is the bedrock of a healthy immune response.
Modulate our Immune System and Build Resilience to COVID-19?
While it is important to take preventive measures like wearing a mask, social distancing etc, to reduce the likelihood of getting infected, it is equally important to enhance, regulate our immune system, control inflammation to build resilience to Covid-19.
When there is an infection, our immune system mounts an effective immune response, infection regresses and helps promote recovery of healthy tissues in our body. When our immune system is dysfunctional or “imbalance”, its ability to fight infection reduces significantly and when inflammation is too pronounced, the risk of developing chronic diseases increases. It is a known fact that Immune Dysfunction is the origin of many chronic diseases.
Therefore modulating and regulating our immune system to combat against the Covid-19 is crucial to develop sustainable immunity over time.
How can Caviarlieri, a Swiss Caviar Cellular Therapy supplement help regulate your immune system and reduce your inflammation?
Sustainable Immunity – Immunomodulating Properties of Caviarlieri
Caviarlieri is formulated with potent bioactive ingredients like Sturgeon Caviar DNA cellular extract and high quality marine peptides and marine collagen peptide which are extremely rich in DHA and EPA (essential fatty acids) known to enhance B cell activity, which could be useful for those with a compromised immune system.
Manufactured using a proprietary Swiss cold extraction technology, Cellularix, the ingredients are kept “active” so that the chemical integrity and potency of the micro nutrients are not destroyed or compromised. This will help optimize our absorption of the micro nutrients into the body and maximize the outcomes and results.
In addition, the Caviarlieri is made of potent peptides which help to escort the nutrients into our cells for protein synthesis which is an important process to accelerate cellular renewal and repair versus damaged cells. If essential nutrition is provided at the cellular level, it will help maintain or strengthen the functionality of our immune system and potentially provide cellular immunity
One of the key ingredient of Caviarlieri is Marine Collagen peptides. These peptides are known to modulate 3 key factors for effective immune response – Inflammation, Tissue Damage, Oxidative Stress. For people with a compromised or dysfunctional immune system, immune modulating is vital.
Most of the fatalities related to Covid-19 are attributed to cytokines storm or hyperinflammation. A key aspect of our immune system is associated with the communication of cells which is mediated by cytokines, a broad category of enzymes or chemical messengers of the cells. Cytokines play a beneficial and detrimental role to our immune response. Apart from triggering inflammation, they are also involved in healthy tissue turnover and promote the remodeling of ECM (Extra Cellular Matrix). Extracellular matrix provides support and anchorage for the shape of the cells, regulates and determines cells dynamic and behavior including cell survival, cell proliferation, cell polarity, cell differentiation, cell adhesion, and cell migration.
The goal for a balanced immune health system is therefore to reduce cytokines concentration without blocking its production.
The scientific studies on Caviarlieri published in peer reviewed journals have proven that it has powerful antioxidant properties which can potentially prevent damage to the immune cells by neutralizing free radicals. Free radicals are substances in the environment that can damage cells and reduce immunity. Supplementing with Caviarlieri can also help increase the activation of cells involved in regulating our immunity.
Another active ingredient of Caviarlieri is Selenium. This potent antioxidant keeps our immunity in check by identifying and warding off potentially harmful threats, like viruses, parasites and bacteria. It is also known to help regulate our immune responses and protect us against infectious microorganisms.
Significant Reduction and Regulation of Inflammation
Caviarlieri is scientifically proven to help reduce the Tumour Necrosis Factor Alpha which is an important inflammatory biomarker for metabolic syndrome conditions. In addition, Caviarlieri can also reduce the C-reactive protein (CRP), a blood test marker for inflammation in the body. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation.
There are also several current and ongoing studies which indicate that Caviarlieri triggers the epigenetic mechanisms of the cells to activate gene expression for inflammation reduction which will help alleviate the onset of any of the risks associated with the diseases as a consequence of metabolic syndrome.
Note: Metabolic syndrome is a cluster of conditions such as high blood pressure, high blood sugar, unhealthy cholesterol levels, excess abdominal fat that increases your risk of heart disease, stroke and type 2 diabetes.
- Published in Peer Reviewed Journal – Acta Bio Medical / Official Journal of the Society of Medicine and Natural Sciences of Parma Vol 84-53-60/2013
- A sturgeon-derived bioactive compound beneficially modulates nuclear receptors controlling metabolic functions in patients with metabolic syndrome
- A. Lorenzetti, R. Catanzaro, G. Bertuccelli, N. Zerbinati, . Jain, U. Solimene, S.K. Yaduvanshi, N. Srivastava, E.Minelli, H. Yadav, C. Tomella, F.Marotta
The aim of the study was to test the possible effects of a novel sturgeon-derived compound Caviar DNA Extract (LD-1227) on inflammatory markers related to metabolic nuclear receptors in patients with metabolic syndrome. The study population consisted of 76 patients with metabolic syndrome and 30 healthy subjects who were maintained to their current treatments and randomly supplemented with A) Caviar DNA Extract (LD-1227) (n=38) or B) placebo (n=38) as compared to C) healthy controls (n=30). Caviar DNA Extract (LD-1227) or placebo (water-soluble starch) were given daily at breakfast and dinner for three months.
At the end of the study period, as compared to B group, Caviar DNA Extract LD-1227-treated patients showed a significant improvement of all parameters (hs-CRP, IL-6, TNF-alpha) tested, irrespective of the presence of diabetes. The study’s findings show that although the metabolic syndrome remains a multifaceted condition requiring a complex approach, Caviarlieri (LD-1227) could be a potential safe therapeutic tool to be integrated into a wider treatment and preventive medicine schedule strategy.
After intervention with Caviar DNA Extract (LD-1227), TNF-α level (inflammation) decreased significantly in all Metabolic Syndrome patients (p<0.05 vs baseline and vs placebo group).
The level of hs-CRP in patients with Metabolic Syndrome was significantly higher than in healthy controls (p<0.05, fig 2) and particularly in those with overt diabetes (p<0.05 vs MS patients without diabetes). After intervention with Caviar DNA Extract (LD-1227), hs-CRP significantly decreased (p<0.05 vs placebo).
Note: C-reactive protein (CRP) is a blood test marker for inflammation in the body. CRP is produced in the liver and its level is measured by testing the blood. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation. A high-sensitivity C-reactive protein (hs-CRP) test, which is more sensitive than a standard test, also can be used to evaluate your risk of developing coronary artery disease, a condition in which the arteries of your heart are narrowed. Coronary artery disease can lead to a heart attack.
It is evident from the above studies that Caviarlieri is a potent and effective supplement for alleviating metabolic syndrome by reducing inflammation. After administering Caviar DNA Extract (LD-1227), levels of all tested cytokines (inflammatory biomarkers) in Metabolic Syndrome patients markedly decreased whereas their levels remained unchanged in patients receiving placebo. This suggests that Caviar DNA Extract (LD-122 could provide protection for Metabolic Syndrome patients and that this protection was proportionally more evident even for patients with diabetes.
In another peer reviewed study on Caviarlieri, the intervention with Caviar DNA Extract (LD-1227) has shown in human chondrocytes that this sturgeon-derived compound with its marine collagen peptides could effectively inhibit IL-1β-induced proliferation and inflammatory reactions via inhibited activation of the transcription factor NF-κB pathway. Caviarlieri contains collagen elastin, protein and a rich array of other smaller unsaturated fatty acids, and structural phospholipids which may exert a synergistic action on multiple mechanisms of the inflammatory cascade.
Why is Caviarlieri a safe and potent option?
Caviarlieri is not a drug but an oral food supplement approved by the Swiss Public Health Authority. Unlike drugs or medications, there are no side effects for long term use. Caviarlieri is a listed supplement on Cologne List® and therefore undergoes independent quality checks. These are carried out by one of the globally-leading laboratories in nutritional supplement analytics for doping substances.
Manufactured using the Swiss Cold Process Extraction Technology, Cellularix, Caviarlieri comes in a soft gel form which encapsulates the Caviar bioactive nutrients and marine peptides for optimal absorption. It is important to know that not all food supplements are able to do so.
By providing essential nutrition at the cellular level, Caviarlieri triggers protein synthesis and stimulates our own body system to heal, repair and renew our cells at an accelerated rate against damaged cells. Unlike drugs, it will take a 3-6 months regime for the cellular healing and repair to generate maximum benefits and results.
Caviarlieri is also backed by Science as it has several studies published in peer-reviewed journals and the multifunctional benefits are evidence based claims, like significant increase in energy levels, mood elevation, reduction in joint pain, enhancement of sleep quality, improving brain health, reduction in inflammation and many others. These are important benefits which will potentially protect us from the malefic effects of COVID-19.
Sustainable Immunity – Leading a Healthy Lifestyle
Leading a healthy lifestyle is crucial if you desire to have sustainable immunity. Make sure your get enough sleep, exercise regularly, eat a balanced diet and try not to be stressed.
Failing that, vaccination will definitely help improve your immunity. There is only one caveat. Studies have shown that the antibodies after COVID-19 vaccination will last for three months, but the upper limit is not yet known because these vaccines have only been administered for a few months.