Potent Anti-Inflammatory
Properties

Renowned specialists in the biology of aging have identified a rarely recognised yet universal condition – chronic inflammation is a major contributor to a wide range of debilitating illnesses including cardiovascular disease, stroke, heart disorders, cancer, dementia and diabetes. That condition is chronic inflammation, a condition that can undermine the well-being of virtually every bodily system.

Chronic immune-mediated inflammatory diseases like rheumatoid arthritis, autoimmune diseases (Crohn’s disease, Hashimoto’s disease, asthma, ankylosing spondylitis etc.) cause debilitating pain and compromise with the quality of life.

Caviarlieri is scientifically proven to have very strong anti-inflammatory properties. Formulated with the finest Caviar Cellular Extracts, marine peptides and highly polymerized collagen, it can help reduce chronic inflammation by reducing the Tumour Necrosis Factor-alpha and Hs-C Reactive Protein (inflammatory biomarkers), associated with a broad spectrum of degenerative diseases.

Unlike drugs, steroids and painkillers, which have adverse side effects if used for a long period of time, Caviarlieri is an excellent nutritional supplement which has no side effects and is a palliative for chronic pain management.

Scientific studies of Caviarlieri published in peer reviewed journals have demonstrated that its primary bio active ingredient, Caviar DNA Extract can trigger the epigenetic mechanisms of the cells.  This then activates the gene expression for inflammation reduction and as a result significantly reduces joint pains and inhibits cartilage degradation.

Scientific Evidence



Published in Peer Reviewed Journal – Acta Bio Medical / Official Journal of the Society of Medicine and Natural Sciences of Parma Vol 26, No. 3, July-Sep 2012.

BENEFICIAL EFFECT OF A STURGEON-BASED BIOACTIVE COMPOUND ON GENE EXPRESSION OF TUMOR NECROSIS FACTOR-α, MATRIX METALLOPROTEINASES AND TYPE-10 COLLAGEN  IN HUMAN CHONDROCYTES

This study examined a possible inhibitory effect of Caviarlieri – Caviar DNA extract (LD-1227) collagen elastin and protein extracts from sturgeon on ILβ -induced activation and production of TNFα and MMP-13 in human osteo-arthritis (OA) chondrocytes and intracellular signalling factors. Human chondrocytes were derived from OA cartilage and stimulated with ILβ.

Results

The data showed in the following figures indicate that Caviar DNA extract (LD-1227) can inhibit IL-1β-induced proliferation and inflammatory reactions via inhibited activation of the transcription factor NF-κB pathway in human chondrocytes derived from OA patients. These novel pharmacological actions of Caviarlieri on ILβ-stimulated human OA chondrocytes provide evidence that Caviar DNA extract (LD-1227) may inhibit cartilage degradation by suppressing ILβ-mediated activation and the catabolic response in human chondrocytes.

Effect of Caviar DNA Extract (LD-1227) TNF-Alpha Concentration in Culture Medium of Stimulated Chondrocytes

It is evident from the above results that OA chondrocytes (cartilage) cultured with Caviar DNA Extract can significantly lower levels of inflammatory markers like Tumour Necrosis Factor-Alpha , MMP-13, MMP-1 and Collagen type 10 . This means that  the inflammation markers present in the OA  chondrocytes (cartilage) (that were stimulated by IL1b) were significantly reduced when cultured with Caviar DNA Extract (LD-1227).

IMPORTANT: Matrix metalloproteinase 13 (MMP-13) degrades collagenous extracellular matrix and its aberrant activity is associated with diseases such as arthritis, cancer, atherosclerosis and fibrosis.

Note: It is well established that IL-1β stimulates cartilage breakdown. These studies have highlighted the pro-catabolic effects of IL-1 by measuring the expression of inflammatory markers such as MMP levels and cyclooxygenase (COX) and the release of matrix degradation products

Effect of Caviar DNA Extract (LD-1227) on
Gene Expression of MMP-13, MMP-1 and COL10A1
in IL-1 beta
Stimulated Osteoarthritis Chondrocytes

Effect of Caviar DNA Extract (LD-1227) on
Gene Expression of NFkB 65 in IL-1 beta
Stimulated Osteoarthritis Chondrocytes

It is evident from the above graphs that Caviar DNA Extract (LD-1227) suppresses NF-kB activation. The anti-inflammatory potency of Caviarlieri. Is demonstrated by the suppression of NF-kB activation.

Note: NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation.

Conclusion



Osteoarthritis tends to evolve from the local inflammatory disease of articular cartilage to progressive degenerative joint disease with inflammation and degeneration that ultimately results in underlying bone, pain and disability .

From the data obtained in the study, almost complete inhibition of both TNFα and MMPs expression and production was observed at a concentration of 100 μM Caviar DNA Extract -LD-1227 (p < 0.01), demonstrating that Caviarlieri is a promising new approach for the inhibition of cartilage degradation. More importantly it is scientifically proven to have strong anti-inflammatory properties.

Other Evidence-Based Benefits of Caviarlieri

Brain Enhancement

The observed reciprocal response between neuronal and glial populations suggest that Caviarlieri can potentially affect a neuronal lineage of the neural progenitor cells. Thus, Caviarlieri can effectively protect brain degeneration and may stimulate neurogenesis.

Strengthens Immunity

Caviarlieri is formulated with potent bioactive ingredients like Sturgeon Caviar DNA cellular extract and high quality marine peptides which are known to enhance B cell activity and could be useful for those with a compromised immune system.

Substantial Reduction in Joint Pain

Caviarlieri has strong anti-inflammatory properties that can help alleviate and reduce chronic joint pain significantly. Unlike painkillers or opioids which have adverse side effects, Caviarlieri is an excellent nutritional supplement which has no side effects and is a palliative for chronic pain management.