Potent Anti-Inflammatory
Properties

Potent Anti-Inflammatory
Properties

Renowned specialists in the biology of aging have identified a rarely recognised yet universal condition – chronic inflammation is a major contributor to a wide range of debilitating illnesses including cardiovascular disease, stroke, heart disorders, cancer, dementia and diabetes. That condition is chronic inflammation, a condition that can undermine the well-being of virtually every bodily system.

Chronic immune-mediated inflammatory diseases like rheumatoid arthritis, autoimmune diseases (Crohn’s disease, Hashimoto’s disease, asthma, ankylosing spondylitis etc.) cause debilitating pain and compromise with the quality of life.

Caviarlieri is scientifically proven to have very strong anti-inflammatory properties. Formulated with the finest Caviar Cellular Extracts, marine peptides and highly polymerized collagen, it can help reduce chronic inflammation by reducing the Tumour Necrosis Factor-alpha and Hs-C Reactive Protein (inflammatory biomarkers), associated with a broad spectrum of degenerative diseases.

Unlike drugs, steroids and painkillers, which have adverse side effects if used for a long period of time, Caviarlieri is an excellent nutritional supplement which has no side effects and is a palliative for chronic pain management.

Scientific studies of Caviarlieri published in peer reviewed journals have demonstrated that its primary bio active ingredient, Caviar DNA Extract can trigger the epigenetic mechanisms of the cells.  This then activates the gene expression for inflammation reduction and as a result significantly reduces joint pains and inhibits cartilage degradation.

Scientific Evidence



Published in Peer Reviewed Journal – Acta Bio Medical / Official Journal of the Society of Medicine and Natural Sciences of Parma Vol 26, No. 3, July-Sep 2012.

BENEFICIAL EFFECT OF A STURGEON-BASED BIOACTIVE COMPOUND ON GENE EXPRESSION OF TUMOR NECROSIS FACTOR-α, MATRIX METALLOPROTEINASES AND TYPE-10 COLLAGEN  IN HUMAN CHONDROCYTES

This study examined a possible inhibitory effect of Caviarlieri – Caviar DNA extract (LD-1227) collagen elastin and protein extracts from sturgeon on ILβ -induced activation and production of TNFα and MMP-13 in human osteo-arthritis (OA) chondrocytes and intracellular signalling factors. Human chondrocytes were derived from OA cartilage and stimulated with ILβ.

Results

The data showed in the following figures indicate that Caviar DNA extract (LD-1227) can inhibit IL-1β-induced proliferation and inflammatory reactions via inhibited activation of the transcription factor NF-κB pathway in human chondrocytes derived from OA patients. These novel pharmacological actions of Caviarlieri on ILβ-stimulated human OA chondrocytes provide evidence that Caviar DNA extract (LD-1227) may inhibit cartilage degradation by suppressing ILβ-mediated activation and the catabolic response in human chondrocytes.

Effect of Caviar DNA Extract (LD-1227) TNF-Alpha Concentration in Culture Medium of Stimulated Chondrocytes

It is evident from the above results that OA chondrocytes (cartilage) cultured with Caviar DNA Extract can significantly lower levels of inflammatory markers like Tumour Necrosis Factor-Alpha , MMP-13, MMP-1 and Collagen type 10 . This means that  the inflammation markers present in the OA  chondrocytes (cartilage) (that were stimulated by IL1b) were significantly reduced when cultured with Caviar DNA Extract (LD-1227).

IMPORTANT: Matrix metalloproteinase 13 (MMP-13) degrades collagenous extracellular matrix and its aberrant activity is associated with diseases such as arthritis, cancer, atherosclerosis and fibrosis.

Note: It is well established that IL-1β stimulates cartilage breakdown. These studies have highlighted the pro-catabolic effects of IL-1 by measuring the expression of inflammatory markers such as MMP levels and cyclooxygenase (COX) and the release of matrix degradation products

Effect of Caviar DNA Extract (LD-1227) on
Gene Expression of MMP-13, MMP-1 and COL10A1
in IL-1 beta
Stimulated Osteoarthritis Chondrocytes

Effect of Caviar DNA Extract (LD-1227) on
Gene Expression of NFkB 65 in IL-1 beta
Stimulated Osteoarthritis Chondrocytes

It is evident from the above graphs that Caviar DNA Extract (LD-1227) suppresses NF-kB activation. The anti-inflammatory potency of Caviarlieri. Is demonstrated by the suppression of NF-kB activation.

Note: NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation.

Conclusion



Osteoarthritis tends to evolve from the local inflammatory disease of articular cartilage to progressive degenerative joint disease with inflammation and degeneration that ultimately results in underlying bone, pain and disability .

From the data obtained in the study, almost complete inhibition of both TNFα and MMPs expression and production was observed at a concentration of 100 μM Caviar DNA Extract -LD-1227 (p < 0.01), demonstrating that Caviarlieri is a promising new approach for the inhibition of cartilage degradation. More importantly it is scientifically proven to have strong anti-inflammatory properties.

Other Evidence-Based Benefits of Caviarlieri

Brain Enhancement

The observed reciprocal response between neuronal and glial populations suggests that Caviarlieri can potentially affect a neuronal lineage of the neural progenitor cells. Thus, Caviarlieri can effectively protect brain degeneration and may stimulate neurogenesis.

Strengthens Immunity

Caviarlieri is formulated with potent bioactive ingredients like Sturgeon Caviar DNA cellular extract and high quality marine peptides which are known to enhance B cell activity and could be useful for those with a compromised immune system.

Substantial Reduction in Joint Pain

Caviarlieri has strong anti-inflammatory properties that can help alleviate and reduce chronic joint pain significantly. Unlike painkillers or opioids which have adverse side effects, Caviarlieri is an excellent nutritional supplement which has no side effects and is a palliative for chronic pain management.

“I always aspire to lead an active lifestyle regardless of my age but it can be very challenging to sustain energy levels as we age chronologically. My doctor recommended me Caviarlieri and it has transformed my life. Not only do I experience a surge in energy levels, physical stamina, my sleep quality has improved significantly as well.

With the pandemic, many of my friends feel a little stressed, anxious and depressed. Not for me. Caviarlieri elevates my mood and I feel great. It also helps me in my mental focus and concentration. Without a doubt, I am a fan.”

“Caviarlieri works on multiple levels. Most patients reported improved energy levels, better sleep quality, enhanced skin complexion in the first few weeks of taking Caviarlieri. In the sixth week, many of my patients also reported significant reduction in joint pain and inflammation, mood elevation, increased sexual desire and libido, just to name a few.”

“Since I started using Caviarlieri, I noticed a huge improvement in my Stamina and Endurance. Overall, my muscle fatigue and soreness were reduced significantly. My sleep quality has improved tremendously, and my mood is also elevated. I can train harder and I am definitely more focused.”

“Regardless of their age, all of the patients show improvement in energy levels, enhancement in collagen levels, significant reduction in inflammation. This means that Caviarlieri can trigger epigenetics changes, which is really revolutionary and ground breaking. It was a Eureka moment for me as a research scientist to discover a product  which can benefit patients at a molecular, cellular and genetic level, unheard of any other food supplement.”

“One of my 59 year old patient had a lump on her right breast and the doctor recommended to have it removed. After taking Caviarlieri for 3 months, the lump was gone. Another 50 year old patient has joint pain on the knee and after taking Caviarlieri for 2 weeks , the pain was significantly reduced and the swelling and inflammation reduced as well.

Caviarlieri also helps in sexual satisfaction as told by my 60 year old patient. She mentioned that her vaginal lubrication has improved after taking Caviarlieri for few months.”

“As an aesthetic doctor and dermatologist, I really appreciate the outstanding benefits of Caviarlieri. Not only does it improve my skin complexion, I find significant increase in my energy levels and enhancement of sexual desire only weeks after taking the Caviar Supplement.

Based on the scientific studies, it is also evident that Caviarlieri can benefit at a cellular and molecular level, which is unbelievable. It also helps improve my quality of sleep, which is few and precious due to my heavy work schedule.

I have taken this product for more than 6 months and I know I will continue with this product for vitality, youth and beauty.”

“With Caviarlieri, I feel like a young man bursting with energy and vitality even though I am 83 years old. Not only do I feel energised and optimistic, this caviar supplement also helped in my recovery from my quintuple bypass, hip replacement and shoulder replacement surgeries. In spite of my hectic work schedule, my mental focus and concentration are excellent. Furthermore, my students and colleagues always ask me how I manage to be as active as a 38 year old and what the secret to my high energy level is! I know it is because of Caviarlieri.”

“As a Professor in Obstetrics and Gynaecology and a medical expert in IVF discipline, I am sceptical about the benefits and claims of any health supplement unless it is backed by empirical evidence. When I first came to know Caviarlieri, I was impressed by the list of scientific studies published in peer reviewed journals , demonstrating that this caviar supplement is backed by science. I found the evidence in support of Caviarlieri’s use in many therapeutic indications extremely compelling.When I finally got to try Caviarlieri, I was astounded that even though I am over 65 years of age, I feel that I am able to function and work like I did 30 years ago. My mental focus and stamina have increased incredibly and I am able to focus and concentrate on many complex issues simultaneously from early morning to late at night, much to the surprise of my fellow colleagues.I am a living testament to the amazing benefits of this product.”

“Life expectancy is increasing but we need to get it in good health.We want to be optimistic, to maintain our physical appearance, our mechanical functionality and our brain even as we age. Caviarlieri is based on Science. It is proven to help increase energy levels, reduce inflammation for joint pain and increase collagen for our skin and tissues. It’s a wonderful product for depression, brain degeneration and even fibromyalgia. This is the secret of life, of aging and preventing aging. The best thing I can tell you is I am taking it for myself.”

“I am Isabel Bastos,Hhead Therapist of Le Grand Bellevue Gstaad.

I have been very lucky to be the brand ambassador of Caviarlieri.

Why? Because I started to take it and I love the results that I had in my body because im a spa therapist and we lose a lot of energy. My skin really looks better. I am 52.

My bodies issues, they are really getting really really better and the thing that I like more is that my guests had the chance to take it for 3 months and they didn’t want to stop it. Because each of them, in a different way feels the results. In the skin, in the body, a lot of people at this moment, like we know are suffering from COVID and might be feeling a little bit sick but after taking this, they feel more energized, they sleep better and even to their normal life, the things are really getting better. Please try it. Just give it chance, don’t doubt like me because we have thousands of products like this in the world, but this is really special.”

“This is especially important in the most delicate times of a woman, so I don’t lose energy or feel tired. I am extremely happy to say that Caviarlieri is an exceptional supplement, important to my life and will be continuing to take it.”

“I am chief of Internal Medicine and Anti-Aging at the Metropolitan Hospital and the owner of Orthobiotiki Anti-Aging Clinic. The last 7 years I was Vice President of ESSAM, European Society of Anti-Aging Medicine.

The Swiss Cell Treatment, Caviarlieri renews old cells, reduces and controls inflammation and other medical conditions which are age-related.

As an internist, I have discovered that Caviarlieri helps reduce inflammation of the joints significantly in addition to a reduction in the pain. It also helps to lower glucose levels which therefore benefit the diabetics and the non-diabetics. In my opinion Caviarlieri fulfils all the 5 criteria that defines an Anti-Aging product.”

“I am an outdoor sports enthusiast who enjoys travelling, diving, swimming, skiing, fitness and hiking. In late 2017 , while doing my sports activities, I injured my knees and was diagnosed with grade 3 Chondropathy. This is a disease of the cartilage and is caused by inflammation and damage to the knee cartilage. The pain can be difficult at times but I tried to manage. The doctors gave me the usual advice .They told me to avoid the overuse of my knees and to go for physiotherapy treatments.
This potentially meant that I have to avoid engaging in some sports activities indefinitely, which was devastating for me. Dr. Brigitte Bollinger, a reputable dermatologist from Bad Ragaz Medical Center then introduced me to Caviarlieri. She told me that this caviar supplement is able to provide essential nutrition at the cellular level thereby stimulating cellular repair and renewal against the damaged cells in my knees. She assured me that Caviarlieri is backed by science and it is a supplement and not a drug. The results have been phenomenal. After 4 months of taking Caviarlieri, I was amazed at my recovery. I am now able to resume sports and outdoor activities like before. Most importantly I am so thrilled that I am able to ski again and my life has returned back to normalcy.”

“I am a medical doctor who has worked about 60 to 80 hours a week for the past 20 years. I was tired all the time and my sleep was not restful. I started to feel more energy within the first two weeks of taking Caviarlieri. I also gave it to my husband and noticed that his memory has improved significantly. We both sleep better and wake up with more energy. It is expensive but my health is invaluable and I am worth it.”

“The benefits of taking Caviarlieri for me have been significant. Prior to taking them I had been diagnosed with Rheumatoid Arthritis but the symptoms have been 90% improved in the last year.  My asthma symptoms have also improved drastically by 80% and most of the time I have no need for an inhaler.”

“Caviarlieri helps boost my strength and stamina.

I have been taking Caviarlieri for almost 1 year and the benefits I experience from this caviar supplement are extraordinary. The product was recommended to me by Dr. Sotiris Nikolopoulos and Dr. Michael Papacharalampous, both world renowned doctors in Athens.

I was amazed that Caviarlieri – Swiss Caviar Cell Therapy supplement has helped increase my cellular energy significantly , improve my sleep quality and enhance my physical stamina and endurance. Caviarlieri has definitely helped enhance my performance at the Tokyo Olympics 2021.

Henceforth, I will continue to take this supplement as it is a product not only backed by science with peer-reviewed studies and it is also listed in the Cologne List® which is committed to “clean sports” and promotes safety through tested products.”

“I have been taking Caviarlieri for more than 1 year and the benefits I experienced are phenomenal and outstanding. The potency of the product is undeniable, I am invigorated to exercise and my mental concentration has improved significantly. At 86, I am full of life and people are amazed how I am able to walk briskly without joint pain and I can even surpass the work schedule of my employees and my daughters who are responsible for the management of the hospitals. Many people also commented on my skin complexion and glow.

Caviarlieri also helps to regulate my blood sugar levels , reduce
inflammation and is very effective in preventing brain degeneration. I look forward to taking this Caviar Supplement every single morning.”