What is Gene Expression?

Our genes define our potential, our limitations, and our predispositions to disease. Our DNA sequence is inherited from our parents and this cannot be changed. However, the expression of our genes is responsive and can be changed and it is influenced by epigenetics – our lifestyle, including our diet, physical exercise, sleep habits, social interactions, exposure to toxins, psychological stress, and environmental factors.

When the information stored in our DNA is converted into instructions for making proteins or other molecules, it is called gene expression. It acts as both an on/off switch to control when proteins are made and also a volume control that increases or decreases the amount of proteins made by our body. By examining the expression of so many genes simultaneously, it is possible now to begin to identify and study the gene expression patterns that underlie our cellular physiology: we can see which genes are switched on (or off) as our cells grow, divide, or respond to hormones or to toxins.

The process by which a gene gets turned on in a cell to make RNA and proteins is called GENE EXPRESSION. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

What is the purpose of studying gene expression?

Latest Scientific research have shown that the expression of certain genes correlates with biological aging. Unbalanced gene activity is the root of inflammation, stress and hormonal imbalance, ultimately affecting our health-span and overall wellbeing.

In a PubMed study “Genetics of gene expression and its effect on disease” published in the Journal of Nature in 2008, scientists analysed the genetic expression of 23,720 transcripts in large population-based blood and adipose tissue cohorts comprehensively assessed for various phenotypes, including traits related to clinical obesity. They have

discovered that in contrast to the blood expression profiles of obese clinical subjects. There is a marked correlation between gene expression in adipose tissue and obesity-related traits.

In a study published in the journal of Future Medicine in 2011, “Epigenetics and Lifestyle”, it has been identified that several lifestyle factors such as diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants, psychological stress and working on night shifts might modify epigenetic patterns. While genetic changes can alter which protein is made, epigenetic changes affect gene expression to turn genes “on” and “off.” Since our environment and lifestyle behaviours, such as diet and exercise, can result in epigenetic changes, it is easy to see the connection between our genes and our behaviour and environment.

There are several studies which also show that DNA damage which are reflected in the gene expression analysis may result in different Chronic degenerative diseases like cancer, growth retardation, glaucoma etc. depending on the replication rate of the target cell population.

Caviarlieri Genetic Expression Studies on Anti-Aging Biomarkers

Initial in- vivo research studies on Caviarlieri at the molecular level have proven that this Swiss Caviar Cell Therapy supplement is effective in the gene expression of genes related to anti-aging, inflammation (reduction in the expression of Cox2 gene), type 1 collagen and energy (GABPB1 gene).

By providing nutrition at the cellular level, Caviarlieri can trigger protein synthesis and prompt our bodies to produce proteins through active gene induction and thereby stimulating and accelerating cellular renewal and repair against damaged cells.

Mirroring the results of the Caviarlieri studies which have been published in peer reviewed journals, in PubMed and Europe PMC, the current genetic expression studies (mRNA) on Caviarlieri show that this caviar supplement can potentially help to reduce and control inflammation and thereby alleviate the symptoms associated with autoimmune diseases. The studies show that the decrease in the expression of the COX2 gene after ONLY 60 days of treatment of Caviarlieri is up to 60-fold (p <0.001). This is extremely significant.

Taking Caviarlieri supplements over time can therefore activate the body’s own system in cellular renewal and repair against cellular damage through the reduced genetic expression of COX-2.

In-Vivo research studies (at the molecular level) on Caviarlieri for patients from age 18-83 have proven that this caviar supplement is effective in the gene expression of genes related to

KEY ANTI-AGING BIOMARKERS such as the following:

1. COX 2 Gene – Molecular Biomarker for Inflammation
   Inflammation plays a crucial role in the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, obesity, atherosclerosis, chronic obstructive pulmonary disease, arthritis, chronic inflammatory bowel disease and cardiovascular pathologies. Cyclooxygenases (COX-2) are the main mediators of inflammation by catalysing the initial step of arachidonic acid metabolism and prostaglandin synthesis (Ferrer et al.,2019), therefore COX-2 inhibitors might reduce and control inflammation in metabolic ailments and chronic degenerative diseases.


Caviarlieri intake significantly decreased the expression of the COX2 gene after 60 days of treatment up to 60-fold (p <0.001) that presented with increased expression of COX2 compared to the rest of the participants as well as to COX2 gene expression of the control group.

2. Type 1 Collagen Gene – COL1A1
   Collagens are a family of proteins that strengthen and support many tissues in the body, including cartilage, bone, tendon and skin.

3. Energy Gene Expression – GABPB1
Caviarlieri helps increase THE energy levels of participants, which is evident from the enhanced expression of the GABPB1 gene.

Modulation of GABPB1 gene expression by Caviarlieri, albeit in much smaller scale compared to COL1A1 expression, suggests the effect of this supplement in a gene that was previously found to be associated with endurance performance athlete status at least at the genetic level. Positive testimonials received from the study participants IN THE improvement of their energy capacity are in line with the observed effects on GABPB1 gene expression.

Caviarlieri intake increased the expression of the GABPB1 gene after 30 and 60 days of INTAKE BY up to 3-fold (p <0.001) among participants (Figures 7, 8). The increase was significant only for the individuals that presented initially (before CAVIARLIERI intake, day 0) with low GABPB1 gene expression values.

Genetic Expression Studies on Caviarlieri :
a. Modulation of Type 1 Collagen, COX 2 (inflammatory biomarker) and GABPB1 (energy gene)

Conclusion
It is evident from the above genetic expression studies that Caviarlieri is effective in the gene expression of genes related to Key Anti-Aging Biomarkers for participants aged between 18-83 years.

Why Caviarlieri?

Caviarlieri is a Swiss Caviar Food Supplement formulated with the finest Caviar Cellular Extracts and marine peptides and highly polymerized collagen which have strong anti-inflammatory properties and potent antioxidants and is scientifically and synergistically developed to stimulate and trigger our own body system to heal, repair and renew our cells versus damaged cells. By providing bio active nutrition at the cellular level, Caviarlieri helps to accelerate protein synthesis and cellular repair.

Caviarlieri is Backed by Science

Prior to the recent studies on mRNA and genetic expression, Caviarlieri already has several Peer Reviewed Scientific Studies published in PubMed and PMC Europe. The benefit claims , like significant increase in energy levels, mood elevation, reduction in joint pain, enhancement of sleep quality, improving brain health, strong anti-inflammatory properties and many others are therefore evidence based. It is important to remember that healing begins at the cellular level. These studies demonstrate Caviarlieri’s effective therapeutic outcomes and its ability to modulate and modify disease-related processes.

Caviarlieri is NOT A DRUG but a potent oral food supplement approved by the Swiss Public Health Authority. Unlike drugs or medications, there are no side effects for long term use. Caviarlieri is also certified by the German Sport University, Cologne as being free of steroids, hormones and stimulants which makes it safe for long-term use. Caviarlieri is available in the leading Swiss Medical Centres and Luxury Spas as well as selected pharmacies throughout Switzerland.