We are all aware that while age may bring us a wealth of benefits, there is also an increased risk for the onset of age-related degenerative diseases, particularly, brain diseases. According to the World Health Organization (WHO), by 2030, half of the worldwide economic impact of disability will come from brain-related problems.

The good news is that declining brain health and cognitive loss are not inevitable. It is preventable. Research confirms that retaining mental sharpness and fitness requires certain lifestyle changes by us like what and how you eat, our exercise routine, how we deal with life’s challenges,

and how we interact and socialize with others. There are 6 cornerstones of mental fitness that can help sustain your mental fitness and attain the best brain performance possible for you at your stage of your life, whatever that may be.

What is Mental Fitness?

Mental fitness encompasses a variety of brain- based skills, such as learning, problem solving, processing what you see and hear, communicating, and making decisions.

In the late 1980, scientists developed the concept of cognitive or mental reserve. In their studies, they found that there were individuals who had no apparent symptoms of dementia even though they had brain changes consistent with advanced Alzheimer’s disease. These changes were discovered through their autopsies. These individuals did not show symptoms of the disease while they were alive because they had a large enough cognitive reserve which helps to offset the damage .This has enabled them to continue to function as usual.

According to a 2020 study in The British Journal of Psychiatry, there are specific activities which will foster greater mental reserve, including an advanced education and an active lifestyle which are associated with a lower risk for dementia.

How to Optimize Your Mental Health?

1. Step 1:

   Eat a healthy balanced diet

2. Step 2:

   Exercise regularly

3. Step 3:

   Get sufficient sleep

4. Step 4:

   Stimulate your brain

5. Step 5:

   Manage your stress

6. Step 6:

   Take supplements for brain protection

Your brain cells known as neurons are highly specialized and they are engaged in very flexible and contiguously changing networks. Although your brain does not replace its cells as frequently as other organs do, it is continuously reshaping the connections between cells.

Therefore to have optimal mental fitness you need to have your brain in the best possible condition for your current age.

It is a well-established fact that age is the biggest risk factor for many brain diseases, most of which affect the brain structure and function. Alzheimer’s and other forms of dementia cause abnormal proteins to clump together and form plaques and tangles that damage our brain tissue. Other diseases that are more common in older adults, such as diabetes and heart disease, can also compromise cognitive function. Medications, poor vision and hearing, sleep deprivation, and depression also can interfere with brain function, and thus one’s cognitive ability.

Dementia is the most obvious—and probably most feared—cause of cognitive decline with age. It is not a disease in and of itself, but rather a descriptive term for the progressive loss of memory and other cognitive abilities severe enough to disrupt one’s daily life.

You Are What You Eat

Selecting a brain-healthy diet makes a very appropriate first step in any program to boost brain health.

In the brain, fasting increases the production of brain-derived neurotrophic factors and other proteins that play an integral role in stimulating the growth of new brain cells and improving the plasticity of brain network.

Exercise Regularly

Exercise is also a powerful tool to protect the brain against the detrimental effects of aging. Among other things,

• it rushes oxygenated blood to nourish brain cells and fosters the growth of new blood vessels in your brain
• increases levels of brain-derived neurotrophic factor, a molecule that encourages the growth of new neurons and maintains the health of existing
• improves brain activity related to sustaining mood

According to a 2019 study published in the Journal of the International Neuropsychological Society, a mere 30 minutes of pedalling on a stationary bike increases brain activity and improves the type of memory that helps us to remember names, numbers, and concepts. Each short burst of exercise alters the production of neurotransmitters and nerve growth factors in a way that increases your brain activity. Repeating the process by exercising with some regularity may promote greater capacity in your neural networks, which in effect could enhance your cognitive reserve.

Why Our Brain Needs Sleep?

Sleep is essential for good health. A lack of sleep leaves you physically drained and mentally foggy. Sleep affects virtually every aspect of your health, from immune function to metabolism and memory. Sleep deprivation impairs attention, concentration, working memory, long-term memory, reasoning, and decision making. Recent findings suggest that sleep plays a housekeeping role that removes toxins in your brain that build up while you are awake.

Sleep and Inflammation

Studies show that sleep deprivation causes an increase in inflammatory molecules—including cytokines, interleukin-6, C-reactive protein and others. According to a 2018 study published in the proceeding of the National Academy of Sciences, just one night of lost sleep increases the brain beta-amyloid levels by as much as 5%. A cumulative pattern of sleep loss can lead to decreases in the structural integrity, size, and function of our brain regions like the thalamus and hippocampus, which are especially vulnerable to damage during the early stages of Alzheimer’s disease.

Engage in Activities That Challenge Your Brain

Participating in intellectually challenging activities promotes brain plasticity and fosters the process of neurogenesis which is the birth of new neurons in your brain. People who have led more intellectually robust lives thanks to their education, work, and leisure activities have more cognitive reserve and appear to face a lower risk of developing dementia as they age.

Manage your stress

Stress is the state of mental or emotional strain, or tension, that results from adverse or very demanding circumstances. Many studies link excessive ongoing stress with heart disease, stroke, headaches, back pain, trouble sleeping, and irritable bowel disorder. Continuous stress also affects your brain.

Supplements for Brain Health

Many supplements are touted for cognitive health, but the evidence is not as strong as the marketing might suggest as it is not evidence based.

• Folic acid is essential to brain function and emotional health. It is a component of DNA and RNA, which are part of the body’s genetic material, and is used in cells of the brain and THE central nervous system. Folic acid also affects the production of neurotransmitters in the brain. It increases nitric oxide in the brain, which protects against oxidative damage. However, there is no conclusive evidence that folic acid supplements can improve cognitive function in healthy older adults or in people with Alzheimer’s disease or other forms of dementia.
• Omega-3 fatty acids DHA, an omega-3 fatty acid, is an essential component of brain cells. Low omega-3 levels have been found in people with Alzheimer’s disease. Research suggests that diets high in omega-3 long-chain polyunsaturated fatty acids might protect cognitive function. Yet studies have concluded that omega-3 supplements do not improve cognitive function in healthy older adults or effectively treat dementia.
• Vitamins B6 and B12 Vitamins B6 and B12 are essential for normal brain function as you age. Deficiencies in these B vitamins have been linked to elevated homocysteine levels, which are associated with an increased risk for dementia. Yet in studies, supplements of these vitamins did not improve cognition in healthy middle-aged and older adults.

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Caviarlieri – A Swiss Caviar Cellular Therapy Supplement

“Delay the Onset and Progression of Brain Degenerative Disease”

Caviarlieri, a potent Caviar Supplement with potent antioxidants, is scientifically and synergistically developed to stimulate and

trigger our own body system to heal, repair and renew our cells versus damaged cells. By providing bio active nutrition at the cellular level, Caviarlieri helps to accelerate protein synthesis and cellular repair.

A peer reviewed in vitro study of Caviarlieri published in PubMed and Europe PMC demonstrates that Caviarlieri, a Swiss Caviar supplement facilitates the differentiation of the whole set of brain cells (neurons, astrocytes and oligodendrocytes). The observed reciprocal response between neuronal and glial populations suggest that Caviarlieri can potentially affect a neuronal lineage of the neural progenitor cells, and it therefore has the ability to generate both neuronal and glial cells. Thus, Caviarlieri can effectively protect degeneration in some integral parts of the brain, specifically the Hippocampus and may be able to stimulate neurogenesis in the mature brain.

EFFECTIVE PROPERTIES OF A STURGEON-BASED BIOACTIVE COMPOUND (Caviarlieri) ON STRESS-INDUCED HIPPOCAMPAL DEGENERATION AND ON IN VITRO NEUROGENESIS

F Marotta, DH Chui, H Yadav, A Lorenzetti, Celep G, S Jain, A Bomba, A Polimeni, K Zhong, F Allegri
Journal of Biological Regulators & Homeostatic Agents
Volume 26 Number 3, July-September 2012

The aim of this study was to test the activity of a marine bioactive compound containing high-purity caviar-derived DNA, collagen elastin and protein extracts from sturgeon to exert neuroprotective properties in an experimental setting while also being potential triggers of neurogenesis in a separate in vitro study. Supplementation with high-DHA mixture and Caviar DNA Extract (LD-1227) in Caviarlieri was applied for 30 days to stress model rats. Both supplementations significantly mitigated the histological brain damage when analysing hippocampal subregions and corticosterone level. However, Caviar DNA Extract (LD-1227) was most significantly efficient in preventing SOD, Catalase and ascorbic acid decrease in brain tissue as compared to DHA.

Rats were subjected to immobilization stress and given orally (or mixed in their regular diet) as follows:

• Group A- regular chow food
• Group B- natural fish oil rich in DHA (10 mg) mixed into regular food
• C- Caviar DNA Extract (LD-1227) 10 mg given orally with their regular diet

Group A demonstrated neuron cell degeneration in CA1, CA2, Ca4 and also in Dg of hippocampus compared to the control (healthy) group. Nerve cell degeneration was observed in almost all 6 layers of the hippocampus. It is evident that in Group B (DHA )and Group C (Caviar DNA Extract), the number of degenerating cell bodies were significantly reduced and to a comparable extent. Cell bodies of all six layers of the hippocampus demonstrated normal neuronal morphology.

Results stress marker:

Corticosterone activity was significantly increased (156.6 µg/100ml) in rats after applying the stress regimen. Corticosterone level almost doubled in stressed animals and Caviar Extract (LD-1227) treatment and DHA brought about a comparable partial improvement in stress levels (p<0.01 vs stressed animals).

Ascorbic acid content in the brain tissue, which can be a preliminary marker of stress, decreased in stress treated animals (1.4 mg/100ml) as compared to healthy control (2.4 mg/100 ml of tissue; p < 0.01). After treatment with Caviar Extract (LD-1227), an increase in ascorbic acid content was observed and also reached a statistic significance level (p < 0.01). The values shown are almost close to the healthy control group.

Accordingly, the SOD activity was significantly decreased by over 33% in stressed animals as compared to control (p < 0.005), and it was restored only in the C group who were treated with Caviar Extract (p<0.05 vs B group, p<0.001 vs A group).

Catalase level in the experimental groups demonstrated a significant change as compared to control with a decrease in the A group by 40% and was restored only in C group rats treated with Caviar Extract (Ld-1227) (p<0.05 vs B group, p<0.01 vs A group).

The spontaneous MDA activity was the highest in the stress group (2.9 nmoles/ml) when compared to respective concentration of MDA in rats treated with either supplement in which the content normalized (A group vs healthy control: p <0.001) (Table 2).

Conclusion:
Both supplements stimulated neurogenesis in vitro and neurons marker in particular but the markers such as oligodendrocytes and glia increased only in those who took the Caviar Extract (LD-1227)-enriched medium. Taken together these data suggest that Caviar Extract (LD-1227) in Caviarlieri is able to significantly protect brain structure redox system at a higher degree than DHA.

Brain Protection Study – Caviarlieri

In another peer reviewed study published in the Journal of Clinical and Diagnostic Research, it was evident that the supplementation of Caviarlieri can lead to a significant increase in the levels of BDNF. BDNF stands for Brain-derived Neurotrophic Factor which is a protein that promotes the survival of nerve cells by playing a role in the growth, maturation, and maintenance of these cells. With the nerve cells survivability enhanced, this will potentially help prevent the occurrence of degenerative symptoms. BDNF also generates therapeutic effects for metabolic and neurological diseases.

A Double-Blind, RCT Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection

Abstract Introduction:
The aim of this prospective study was to see whether LD-1227, a quality-controlled marine nutraceuticals shown to protect experimental stress-induced hippocampal degeneration, could beneficially modulate BDNF, as measured in the serum, in otherwise healthy but work-stressed individuals.

Conclusion:
It appears that there is a beneficial effects of LD-1227 on measures of psychological well-being and related anxiety in healthy and healthy-stressed individuals as well as salivary stress markers and concomitant increase of serum level of BDNF. This may suggest longer term studies in view of a neuroprotective strategy against stress-induced neurodegeneration.

According to the study, we cannot rule out that Caviarlieri may contain other smaller unsaturated fatty acids, structural phospholipids and neurotransmitter precursors, which may to pass through blood-brain barrier and which remain to be defined by further ongoing studies.

Key Ingredients of Caviarlieri

Caviarlieri – Caviar Swiss Cell Therapy Supplement is synergistically formulated the following potent key bioactive ingredients:

Caviar Cellular DNA Extracts and Marine Peptides
One of the key ingredients of Caviarlieri is the Caviar Cellular DNA extract with Marine peptides, which can help in the rejuvenation and revitalization of cells. These bio marine compounds have also been found to have a positive effect on basic mechanisms that affect key inflammatory molecules involved in metabolic syndrome.

In addition, these extracts have strong antioxidant properties which can potentially help to reduce oxidative stress in the brain.

Marine Collagen and Elastin Plus
Collagen is a protein that forms connective tissues throughout the body and it has 20 amino acids/ peptides that aid in brain and memory support of your brain. It is known that aging slows down the production of collagen. The Marine collagen in Caviarlieri has a relatively high percentage of natural peptides such as Glycine and others which contribute to healthy neurological and cognitive function. Other benefits of marine collagen include improvement in sleep quality, better focus and reduction in anxiety levels.

Collagen studies are also underway to discover its capacity to protect brain cells against Amyloid-Beta proteins which are widely thought to cause Alzheimer.

Coenzyme Q10
Mitochondria is a part of the cell that generates energy. For brain cells, it is the main energy-generator. With aging, mitochondrial function decreases and its total dysfunction can lead to death of the brain cells which result to cognitive decline in diseases like Alzheimer’s and Parkinson’s.

The brain is very vulnerable to oxidative damage because of its high demand for oxygen and high fatty acid content. Co-enzyme q10 reduces the proliferation of these harmful compounds to slow down progression of neurodegenerative diseases. Antioxidant stores in the body also decline with age. Co-enzyme Q10 has the potential to improve brain function due to ITS established benefits on mitochondrial function, vascular function and oxidative stress, all of which contribute largely to overall brain health.

Selenium
Selenium is a trace mineral and may not be deemed as necessary to the body as many other minerals and studies show that Selenium can potentially contribute to our brain health and even help alleviate depression.

One notable study states THAT “Selenium is an essential trace element that is vital for the proper functioning of several selenoproteins involved in THE antioxidant defence within the brain and nervous system”.

Selenium has antioxidant properties that help supplement decreasing antioxidant levels in aging as well as reducing free radicals that have negative effects to the brain. Selenium serum level is also associated with decreased cognitive function and it IS evident that patients suffering from Alzheimer’s have lower blood levels of selenium.

The combination of these potent ingredients and their therapeutic effects make Caviarlieri a necessity for brain protection and for delaying the progression of age related brain degenerative diseases.

Why Caviarlieri

Caviarlieri is NOT A DRUG but a potent oral food supplement approved by the Swiss Public Health Authority. Unlike drugs or medications, there are no side effects for long term use. Caviarlieri is on Cologne List®.

Good brain health is more than the absence of disease. It is about optimizing your brain function as you age. The case for adopting a brain-healthy program is compelling for all of us as we age. In the process, you will not only lower your risk for age-related cognitive decline and brain diseases, but you will also improve your overall health and well-being. It is about increasing not just your life span, but also your “health span.” You will be glad that you did in time.