What is Joint Pain?

Joint discomfort is very common and usually felt in the hands, feet, hips, knees, or spine. The pain may be constant or temporary. Some people complain about stiff or sore joints while others complain about a burning or throbbing sensation. For some, their joints may feel stiff in the morning but with movement and activity, their conditions may improve. At the same too much intense activity can worsen the joint pain.

Joint problems and diseases worldwide today rank fifth amongst all forms of disability, affecting 10 percent of the world’s population over the age of 60. It is also estimated that degenerative joint disorders will affect 130 million individuals worldwide by the year 2050.

Nearly 1 in 4 U.S. Adults Affected by Joint Pain, Stiffness

CDC (Centers for Disease Control and Prevention) Report

Conditions like arthritis and gout that cause stiff and painful joints affect almost 1 in 4 adults in the United States, a new Federal report says, and the numbers are growing as the population gets older. As a result, many of these people — nearly 44% — are physically limited and can’t fully take part in activities like hobbies or housework. According to the findings, the prevalence of people suffering from joint pain have been increasing at a phenomenal rate.

Researchers estimated that 24% of adults in the U.S. — or about 58.5 million people — have been diagnosed with general arthritis, rheumatoid arthritis, gout, lupus, or fibromyalgia between 2016-2018. The number has increased by 4.1 million from the CDC’s previous set of estimates that covered the years 2013-2015.

The researchers also estimated that 25.7 million people — 44% of those with arthritis conditions and 10% of all U.S. adults face limitations on their activities because of their joint stiffness and pain. The limitations can be especially grueling in some cases, and may have reached the point where they are unable to plan ahead which days to shop for groceries, do housework, run errands, or even interact with friends and family as their degree of pain and fatigue from arthritis will inhibit their activities and ability to function.

What are the Treatment Options for Joint Pain?

Depending on the diagnosis of the doctor, a combination of the above treatment options can be considered. The type of treatment selected depends on the underlying cause of the joint pain. Selecting the right treatment is important because chronic joint pain if untreated can result in permanent disability and adversely affect the quality of your life.

Treatment options may include:

• Oral, injectable, or topical medications/Diet changes/Exercise
• Nutritional supplements/Physical therapy/Surgery

Depending on the diagnosis of the doctor, a combination of the above treatment options can be considered. The type of treatment selected depends on the underlying cause of the joint pain. Selecting the right treatment is important because chronic joint pain if untreated can result in permanent disability and adversely affect the quality of your life.

Due to the paucity of effective alternative treatments, it is inevitable that the majority of people suffering from joint pain will be dependent on painkillers and drugs like NASIDs (nonsteroidal anti-inflammatory drugs). This is a very serious problem as many of those drugs and painkillers have adverse side effects. Long-term use of certain NSAIDs can lead to side effects including stomach problems, kidney problems, high blood pressure, fluid retention, and other allergic reactions.

Opioids (also known as narcotics) are also prescribed to treat moderate to severe pain. They too have with long-term use, other side effects such as hormonal dysfunction including reduced fertility and libido, immunosuppression, testosterone depletion, and abnormal pain sensitivity. NASIDs and Opioids also become less effective after some time.

How Can Caviarlieri – A Swiss Caviar Cell Therapy Supplement Help Reduce Joint Pain Substantially and Reduce Inflammation?

Caviarlieri is a Swiss Caviar Food Supplement formulated with the finest Caviar Cellular Extracts and marine peptides and highly polymerized collagen which have strong anti-inflammatory properties that can help alleviate and reduce chronic joint pain significantly.

Caviarlieri – Swiss Caviar Cellular Therapy Supplement

Unlike painkillers or opioids which have adverse side effects, Caviarlieri is an excellent nutritional supplement which has no side effects and is a great palliative for chronic pain management. Scientific studies of Caviarlieri published in peer reviewed journals have demonstrated that its primary bio active ingredient, Caviar DNA Extract is more effective than taking DHA and its positive results become more significant over time (18 weeks).

Empirical randomised double-blind placebo studies of the key ingredients of Caviarlieri also show outstanding results for knee osteoarthritis and back pain. In the clinical studies it was found that Caviarlieri is also able to reduce the Tumour Necrosis Factor Alpha which is an important inflammatory biomarker for arthritis and fibromyalgia. There are also several ongoing studies which indicate that Caviarlieri triggers the epigenetic mechanisms of the cells to activate gene expression for inflammation reduction.

Caviarlieri is Scientifically Proven as an Effective Treatment for Osteoarthritis

• More than 80% showed improvement in Functional Mobility
• Reduces Inflammatory Biomarkers TNF alpha and Hs-CRP
• 80% stopped taking NSAIDS drugs after 4 weeks

1. Published in Peer Reviewed Journal – Acta Bio Medical / Official Journal of the Society of Medicine and Natural Sciences of Parma Vol 84-N1/2013 (https://pubmed.ncbi.nih.gov/24 198760)

Testing a novel bioactive marine nutraceutical (Caviarlieri) on Osteoarthritis patients

This study highlights the effect of Caviar DNA extract (LD-1227) on MMPs, collagen metabolism and on chondrocyte inflammatory markers. The primary objective of the study was to test the effectiveness of the Caviar bioactive compound versus a common nutraceutical intervention like GC (glucosamine/chondroitin sulphate) in knee osteoarthritis patients. The patient population involved in the study consisted of 60 subjects who had a recent diagnosis of knee osteoarthritis of mild-moderate severity. The patients were randomized in two groups in a double-blind study comparing Caviar Extract LD-1227 (group A) versus a mixture of glucosamine (500 mg), chondroitin sulphate (400 mg) (group B). Patients were allowed their established painkillers on demand. At 4, 9 and 18 weeks patients were evaluated based on various validated pain score systems like VAS score which assesses pain at rest, and during physical exercise, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale and KOOS scale.

Pain During Physical Activity (VAS Score) through week 18: Effect of Caviar DNA Extract versus GC Glucosamine Chondroitin Treatment

Figure 2 shows the assessment of pain during routine physical activity and it is obvious that both treatments yielded comparable improvement at the 4th week. However, from week 9th till week 18th, patients treated with Caviar DNA extract (LD-1227) showed a significantly lower pain intensity as compared to those on GC.

Note: VAS Score is a 0-100mm Visual Analog Scale Score system which assesses pain during the most painful knee movement.

Figure 3 shows that once again that Caviar DNA extract (LD-1227) can help reduction in pain and is a outstanding option for pain management in the long term.

Note: KOOS (Knee disability and Osteoarthritis) score system is divided into 5 segments namely pain symptoms, function in daily living, function in recreation, other symptoms and quality of life.

Figure 4 shows that patients treated with Caviar DNA extract (LD-1227) have excellent sustainable improvements in recreational functionality from baseline to week 18 as compared to GC.

Figure 5 confirmed and reinforced the results and outcomes measured using VAS Score and KOOs score system in terms of significant pain reduction for Knee Osteoarthritis patients administered with Caviar DNA extract (LD-1227) as compared to GC.

Note: WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index)

Figure 6 demonstrates that patients administered with Caviar DNA extract (LD-1227) have reported significant reduction in the stiffness of their joints from baseline to 18th week compared to GC.

Biochemistry Analysis – Blood tests

Patients in the two groups were tested for inflammatory markers like Tumour Necrosis Factor Alpha, C Reactive Protein, Interleukin 6 etc, cytokines during the 18 weeks study period after taking the Caviar DNA extract (LD-1227) versus those taking GC.

The above table demonstrates that patients administered with Caviar DNA extract (LD-1227) have demonstrated significantly Lower Inflammation over time as compared to GC. This implies that Caviarlieri can not only help to reduce joint pain over time but more importantly, chronic inflammation. This will enhance the recovery process for Osteoarthritis patients.

Conclusive Summary
Most doctors usually prescribe Glucosamine Chondroitin for osteoarthritis patients suffering from joint pain. However, it is evident from the above studies that Caviarlieri is far more potent and effective for the long-term reduction of joint pain compared to the widely prescribed glucosamine chondroitin. In addition, Caviarlieri’s strong anti-inflammatory properties will also reduce disability, enhance recovery and functional physical mobility significantly.

2. Empirical Randomised Double Blind Placebo Clinical Studies on Key Ingredients of Caviarlieri on Osteoarthritis

Effect of Caviar & Marine Cellular DNA Complex on Osteoarthritis after a month.

This explains how patients who were administered with Caviar & Marine Cellular DNA after a month have all reported significant improvements in their physical performance. 21% of the patients also reported complete relief from pain.

Effect of Caviar & Marine Cellular DNA Complex on Osteoarthritis after 24 days

This explains the reduction of pain between treatment with Caviar & Marine Cellular DNA Complex versus Diclofenac. After 42 days, patients who were treated with Caviar & Marine Cellular DNA reported a 39% reduction in pain.

Potential Cartilage Repair or Growth

Conclusion: It is evident, from both the Caviarlieri scientific studies and empirical studies on the key ingredients of Caviarlieri, that there is consistency in terms of sustainable results and outcomes in significantly reducing joint pain, improving functional mobility and the quality of life for Osteoarthritis patients without adverse side effects over time.

Caviarlieri’s Significant Reduction of Inflammation – TNF Alpha

Caviarlieri is also scientifically proven to help reduce the Tumour Necrosis Factor Alpha which is an important inflammatory biomarker for metabolic syndrome conditions. In addition, Caviarlieri can also reduce the C-reactive protein (CRP), a blood test marker for inflammation in the body. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation.

The peer reviewed studies show that the intervention with Caviar DNA Extract (LD-1227) has shown in human chondrocytes that Caviarlieri could effectively inhibit IL-1β-induced proliferation and inflammatory reactions via inhibited activation of the transcription factor NF-κB pathway. Caviarlieri contains collagen elastin, protein and a rich array of other smaller unsaturated fatty acids, and Caviarlieri is a Swiss Caviar Food Supplement formulated with the finest Caviar Cellular Extracts and marine peptides and highly polymerized collagen which have strong anti-inflammatory properties.

Patients with autoinflammatory disease such as gout and those with autoimmune rheumatic diseases (ARD), such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, ankylosing spondylitis and vasculitis among others, have increased prevalence of metabolic syndrome.

Note: Metabolic syndrome is a cluster of conditions such as high blood pressure, high blood sugar, unhealthy cholesterol levels, excess abdominal fat that increases your risk of heart disease, stroke and type 2 diabetes.

Caviarlieri is Backed by Science

Prior to the recent studies on mRNA and genetic expression, Caviarlieri already has several Peer Reviewed Scientific Studies published in PubMed and PMC Europe. The benefit claims are therefore evidence based, like significant increase in energy levels, mood elevation, reduction in joint pain, enhancement of sleep quality, improving brain health, strong anti-inflammatory properties and many others. It is important to remember that healing begins at the cellular level. These studies demonstrate Caviarlieri’s effective therapeutic outcomes and its ability to modulate and modify disease-related processes.

Caviarlieri – Natural Relief Without Side Effects

Caviarlieri is NOT A DRUG but a potent oral food supplement approved by the Swiss Public Health Authority. Unlike drugs or medications, there are no side effects for long term use. Caviarlieri is also certified by the German Sport University, Cologne as being free of steroids, hormones and stimulants which makes it safe for long-term use. Caviarlieri is available in the leading Swiss Medical Centres and Luxury Spas as well as selected pharmacies throughout Switzerland.