What is Chronic Low-Grade Inflammation?

Inflammation refers to your body’s process of fighting against things that harm it, like infections, injuries, and toxins, in an attempt to heal itself. When something damages your cells, your body releases chemicals that trigger a response from your immune system.

This response includes the release of antibodies and proteins, as well as increased blood flow to the damaged area. In the case of acute inflammation, like getting a cut on your knee or dealing with a cold, the whole process usually lasts for a few hours or a few days.

Chronic inflammation happens when this response lingers, leaving your body in a constant state of alert. Over time, chronic inflammation may have a negative impact on your tissues and organs.

When you have chronic low-grade inflammation, your body is in a constant state of high alert, affecting many areas of your body. Left unchecked, it can silently promote multiple diseases, including heart disease, stroke, diabetes, cancer, Alzheimer’s disease, arthritis, bowel diseases like Crohn’s disease and ulcerative colitis.

The World Health Organization ranks chronic diseases as the greatest threat to health. Chronic inflammatory diseases — including stroke, heart disorders, cancer, and diabetes are the most significant cause of death worldwide. The alarming fact is that three out of every five people around the world die from a disease that has been linked to inflammation:

• Heart and blood vessels: Atherosclerosis (hardening of the arteries), heart disease
• Digestive system: Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis
• Joints: Some forms of arthritis, including rheumatoid arthritis and psoriatic arthritis
• Lungs: Allergies, asthma, COPD, lung cancer
• Brain and spinal cord: Alzheimer’s disease, multiple sclerosis, Parkinson’s disease
• Eyes: Macular degeneration, retinal degeneration, uveitis
• Skin: Acne, eczema, psoriasis, skin cancer
• Kidneys: Chronic kidney disease, kidney failure, nephritis
• Pancreas: Type 1 diabetes
• Thyroid: Thyroiditis
• Liver: Chronic hepatitis

Yet, because chronic inflammation can continue for a long time, it’s not easy to know its exact impact on your body.

How is Chronic Inflammation Diagnosed?

There are no real tests to diagnose inflammation on its own. But certain blood tests are a good starting point, including ones that highlight C-reactive protein (CRP), which indicates infections or inflammation in the general body (like the joints), and high-sensitivity C-reactive protein (hsCRP), which reflects inflammation of the heart.

Many individuals don’t know they have chronic inflammation until they are diagnosed with another condition. If you feel like that you ARE experiencing some of the common symptoms of chronic inflammation, it IS a good idea to speak with your doctor. They WILL know the first REMEDIAL steps to take when it comes to a diagnosis.

What are the treatment options for Chronic Inflammation?

Inflammation is a natural part of the healing process. But when it becomes chronic, it’s important to try to get it under control to reduce your risk of long-term damage. Some of the options that’ve been explored for managing inflammation include:

• Nonsteroidal anti-inflammatory drugs (NSAIDs). Over-the-counter NSAIDS like aspirin, (Advil), and naproxen (Aleve), effectively reduce inflammation and pain.
  
  But long-term use is associated with an increased risk of several conditions, including peptic ulcer disease and kidney disease.

• Steroids. Corticosteroids are a type of steroid hormone. They decrease inflammation and suppress the immune system, which is helpful when it starts attacking your healthy tissue. But long-term use of corticosteroids can lead to vision problems, high blood pressure and osteoporosis.

Therefore avoiding the long term usage of drugs will help you to prevent the build-up of toxins and pollutant within your body which will create adverse side effects and potentially chronic inflammation in the process.

How can we possibly guard against chronic inflammation and manage chronic inflammation without the long term use of Drugs?

Recent studies have shown that chronic inflammation can trigger debilitating illnesses from cardiovascular disease to dementia and knowing how to modify your lifestyle and learning the practical steps to do so may help you to manage chronic inflammation and help prevent the onset and progression of chronic degenerative diseases.

Some of the lifestyle modifications that will help you are listed below:

1. Diet and Nutrition
Work on a healthy diet to avoid pro-inflammatory food. These are foods that are processed and include carbohydrates, high sugars, unhealthy fats. A well-balanced diet is vital for building your body’s immune system and healing power. That’s why nutrition can be your ally in fighting pain and inflammation. Some foods are known to have anti-inflammatory properties. These include foods that are high in antioxidants and polyphenols:

• Colourful fruits and vegetables like such as leafy greens, avocados, beets and berries, are rich in antioxidants.
• Fish like Salmon, tuna, trout, mackerel and herring are high in these omega 3 fats. Soy-based foods, walnuts, pecans and ground flaxseed are also good fats.
• Other food like lentils and beans; nuts and seeds; whole grains; green tea; and certain spices, such as ginger and turmeric are also known for their anti-inflammatory properties.

A study published in PubMed in 2018 found that participants following a Mediterranean diet had lower markers of inflammation.

Pro-inflammatory Food to avoid.

The following foods have been known to increase inflammation in some people:

• Highly refined oils and trans fats.
• Refined carbohydrates, such as sugar, pastries or white bread.
• fried foods, like French fries
• processed meat, like hot dogs and sausage

If you’re trying to reduce chronic inflammation, you should reduce your intake of these foods. You don’t have to completely eliminate them, but you should try to eat them only occasionally.

2. Exercise Regularly to keep fit and maintain a healthy body. Avoiding or quit smoking.

3. Limit and control your alcohol intake

4. Certain supplements may help to reduce inflammation.

Fish oil, lipoic acid and curcumin have all been linked to decreased inflammation – although more studies need to be done. The bioavailability and effectiveness of the supplements which has the anti-inflammatory ingredient may not deliver consistent outcomes and results as this will depend on the extraction technology used in the manufacturing process and the source of its raw material. These processes will have an impact on its effects. More research has to be done to ascertain its optimal dosage for its effectiveness.

5. Try a Scientifically Proven and Evidence Based supplement – Caviarlieri Developed and Made in Switzerland

It is known that most people after the age of 30 have a poor digestive system and this results in the poor absorption of nutrients. This means even if you try to have a healthy diet, the body is unable to break down the food. Caviarlieri is made of peptides, which means that the micronutrients encapsulated in the soft gels will not be destroyed by your stomach acid and the nutrients will be deposited in your small intestine for it to finally make its way to your cells for protein synthesis and cellular renewal and repair.

Caviarlieri, Swiss Caviar Cell Therapy Supplement is lavishly formulated with the finest Caviar DNA Cellular Extracts and Marine peptides and highly polymerized collagen, known for their potent anti-inflammatory benefits. These ingredients are extracted using our Swiss Proprietary Swiss Cold Cellularix DNA extraction technology. These low temperatures of the extraction process will mean that the micro nutrients you take are biologically “active” and potent when you take the product and the inherent benefits of the ingredients are optimized and not compromised. In addition, the peptide are small molecules of amino acids which also ensure that the nutrients are transported to areas where your body requires repair. Most importunately, it ensures the provision of essential nutrients at the cellular level, triggering cellular repair against damaged cells and provide the ammunition to fight oxidative stress. Remember not everything you eat can be absorbed.

Caviarlieri’s Significant Reduction of Inflammation – TNF Alpha

Caviarlieri is also scientifically proven to help reduce the Tumour Necrosis Factor Alpha which is an important inflammatory biomarker for metabolic syndrome conditions. In addition, Caviarlieri can also reduce the C-reactive protein (CRP), a blood test marker for inflammation in the body. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation.

The peer reviewed studies show that the intervention with Caviar DNA Extract (LD-1227) has shown in human chondrocytes that Caviarlieri could effectively inhibit IL-1β-induced proliferation and inflammatory reactions via inhibited activation of the transcription factor NF-κB pathway. Caviarlieri contains collagen elastin, protein and a rich array of other smaller unsaturated fatty acids, and Caviarlieri is a Swiss Caviar Food Supplement formulated with the finest Caviar Cellular Extracts and marine peptides and highly polymerized collagen which have strong anti-inflammatory properties.

Patients with autoinflammatory disease such as gout and those with autoimmune rheumatic diseases (ARD), such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, ankylosing spondylitis and vasculitis among others, have increased prevalence of metabolic syndrome.

Note: Metabolic syndrome is a cluster of conditions such as high blood pressure, high blood sugar, unhealthy cholesterol levels, excess abdominal fat that increases your risk of heart disease, stroke and type 2 diabetes.

Strong Anti-Inflammatory Properties of Caviarlieri

Published in Peer Reviewed Journal – Acta Bio Medical / Official Journal of the Society of Medicine and Natural Sciences of Parma Vol 84-53-60/2013

A sturgeon-derived bioactive compound beneficially modulates nuclear receptors controlling metabolic functions in patients with metabolic syndrome.

The aim of the study was to test the possible effects of a novel sturgeon-derived compound Caviar DNA Extract (LD-1227) on inflammatory markers related to metabolic nuclear receptors in patients with metabolic syndrome. The study population consisted of 76 patients with metabolic syndrome and 30 healthy subjects who were maintained to their current treatments and randomly supplemented with A) Caviar DNA Extract (LD-1227) (n=38) or B) placebo (n=38) as compared to C) healthy controls (n=30). Caviar DNA Extract (LD-1227) or placebo (water-soluble starch) were given daily at breakfast and dinner for three months.

At the end of the study period, as compared to B group, Caviar DNA Extract LD-1227-treated patients showed a significant improvement of all parameters (hs-CRP, IL-6, TNF-alpha) tested, irrespective of the presence of diabetes. Although the metabolic syndrome remains a multifaceted condition requiring a complex approach, Caviarlieri (LD-1227) could be a potential safe therapeutic tool to be integrated into a wider treatment and preventive medicine schedule strategy.

Figure 1a. Time course change of IL-6 In patients with Metabolic Syndrome with/without diabetes: effect of treatment with Caviar DNA Extract (LD-1227). Throughout the whole study, the level of IL-6 was significantly higher in Metabolic Syndrome patients as compared to healthy controls and it was not affected by the presence of diabetes (p<0.05, fig 1). After intervention with Caviar DNA Extract (LD-122), IL-6 level decreased significantly in all Metabolic Syndrome patients (p<0.05 vs baseline and vs placebo group).

Note: Interleukin-6 is a cytokine not only involved in inflammation and infection responses but also in the regulation of metabolic, regenerative, and neural processes.

After intervention with Caviar DNA Extract (LD-1227), TNF-α level (inflammation) decreased significantly in all Metabolic Syndrome patients (p<0.05 vs baseline and vs placebo group).

The level of hs-CRP in patients with Metabolic Syndrome was significantly higher than in healthy controls (p<0.05, fig 2) and particularly in those with overt diabetes (p<0.05 vs MS patients without diabetes). After intervention with Caviar DNA Extract (LD-1227), hs-CRP significantly decreased (p<0.05 vs placebo).

Note: C-reactive protein (CRP) is a blood test marker for inflammation in the body. CRP is produced in the liver and its level is measured by testing the blood. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation.

A high-sensitivity C-reactive protein (hs-CRP) test, which is more sensitive than a standard test, also can be used to evaluate your risk of developing coronary artery disease, a condition in which the arteries of your heart are narrowed. Coronary artery disease can lead to a heart attack.

Conclusion
The intervention with Caviar DNA Extract (LD-1227) has shown in human chondrocytes that this sturgeon-derived compound could effectively inhibit IL-1β-induced proliferation and inflammatory reactions via inhibited activation of the transcription factor NF-κB pathway. Caviarlieri contains collagen elastin, protein and a rich array of other smaller unsaturated fatty acids, and structural phospholipids which may exert a synergistic action on multiple mechanisms of the inflammatory cascade.

Caviarlieri is Backed by Science

Prior to the recent studies on mRNA and genetic expression, Caviarlieri already has several Peer Reviewed Scientific Studies published in PubMed and PMC Europe. The benefit claims are therefore evidence based, like significant increase in energy levels, mood elevation, reduction in joint pain, enhancement of sleep quality, improving brain health, strong anti-inflammatory properties and many others. It is important to remember that healing begins at the cellular level. These studies demonstrate Caviarlieri’s effective therapeutic outcomes and its ability to modulate and modify disease-related processes.

Why is Caviarlieri a Safe and potent Supplement which may help to thwart this silent killer?

Majestic emerald mountain lake in Switzerland

Caviarlieri is NOT A DRUG but a potent oral food supplement approved by the Swiss Public Health Authority. Unlike drugs or medications, there are no side effects for long term use. Caviarlieri is also certified by the German Sport University, Cologne as being free of steroids, hormones and stimulants which makes it safe for long-term use.

Caviarlieri is available in the leading Swiss Medical Centres and Luxury Spas as well as selected pharmacies throughout Switzerland.