Long Term Protection Against Covid-19 – Immune Modulation and Sustainable Immunity

Caviarlieri | Published May 24, 2021

As of May 22nd, a staggering number of more than 3.5 Million people have died from the coronavirus COVID-19 outbreak and there are currently 167 Million confirmed cases in 220 countries and territories. This is unprecedented in history. (Statistics from worldometers.info)

Importance of Covid-19 Vaccination

In what will be an ongoing struggle against Covid-19, vaccines to prevent coronavirus disease 2019 (COVID-19) are perhaps the best and only hope for ending the pandemic.

Stopping a pandemic requires using all the tools we have available. Wearing masks and social distancing helps to reduce your chance of being exposed to the virus or spreading it to others, but these measures are sadly not enough. Vaccines work with your immune system and so it will be ready to fight the virus if you are exposed.

The combination of getting vaccinated and following the safety recommendations to protect yourself and others provides the best protection for you from contracting COVID-19. Ending the COVID-19 pandemic will halt the growing negative impact the virus is having on education, the economy, health care and the countless other activities of our functioning society.

BreakthroughCases’ show Fully Vaccinated can still get COVID-19

COVID-19 vaccination will protect most people from getting sick with COVID-19.

A very small percentage of fully vaccinated people will still get COVID-19 if they are exposed to the COVID-19 virus. These are called vaccine breakthrough cases. Some people might not experience any symptoms whilst others could become sick due to COVID-19.

However, vaccination might make the illness less severe. If you are fully vaccinated, the overall risk of hospitalization and death due to COVID-19 is much lower than among unvaccinated people with similar risk factors.

The COVID-19 vaccines were developed based on the S protein before it was able to contain the other mutations of the virus identified as the “variants” which were discovered. While research suggests that COVID-19 vaccines have lower efficacy against the variants, the vaccines still appear to provide some protection against severe COVID-19 from the variants. Further research is however needed.

In addition, vaccine manufacturers are also creating booster shots to improve protection against the Covid-19 variants.

Can the current covid-19 vaccination help with the B1617 variant?

The world now has a new variant coronavirus mutant spreading from one continent to another — and it looks like it is a tough one to stop.

The World Health Organization declared recently the variant that emerged in India, known as B1617, is officially a “variant of concern” because of its increased transmissibility. Last week, NPR published a story explaining why the variant B1617 could be the fastest-spreading mutant on the planet.

Like other variants of concern, B1617 has more than a dozen mutations. But two mutations in particular have been most disturbing and of great concern, said Ravindra Gupta, a microbiologist at the University of Cambridge. These mutations are found on an important part of the virus — where the immune system attacks.

Each of these mutations — or similar versions of them — have cropped up separately in other parts of the world, including one in California and one in Brazil. Previous studies have shown that these mutations, individually, give the virus an advantage against our immune system. It reduces the ability of our antibodies to fight off the virus.

At the same time, researchers at Emory University performed similar studies with antibodies taken from 15 people who have been vaccinated with either the Pfizer or Moderna shots. These studies show that the antibodies could still neutralize the B1617 variant, but the potency of the antibodies dropped by about sevenfold on average, the authors reported.

Reports of death after COVID-19 vaccination

Over 273 million doses of COVID-19 vaccines were administered in the United States from December 14, 2020, through May 17, 2021. During this time, VAERS ( Vaccine Adverse Event Reporting System) received 4,647 reports of death among people who received a COVID-19 vaccine. CDC and FDA physicians review each case report of death as soon as they are notified and CDC requests medical records to further assess the reports of deaths.

(Statistics from wwwcdc.gov)

There were also reported cases where patients experienced hypersensitivity or allergic reactions, related to neurology, cardiology, haematology (blood disorders) and dermatology.

The Prolonged Battle against Covid-19 Pandemic

In a study on “How Nutrition can help to fight against COVID-19 Pandemic”, it is evident that the nutritional status of individuals has been used as resilience towards destabilization the virus during this COVID-19 pandemic. Optimal nutrition and dietary nutrient intake impact the immune system. Therefore, the only sustainable way to survive in current context is to strengthen the immune system. A proper diet can ensure that the body is in a proper state to defeat the virus. However along with the dietary management guidelines the food safety management and good food practices are compulsory.

Taking food with adequate vitamins A, C, and D, and minerals, including zinc will play a role in the functioning of the immune system.

food board showing adequate vitamins A, C, D and minerals needed for a healthy immune system

Studies have focused on how specific foods or diets might affect the immune response as follows:

  • Soluble fiber switches the immune cells from pro-inflammatory to anti-inflammatory, which helps us to heal faster from infections.
  • Pterostilbene and resveratrol, found in blueberries and red grapes, respectively, help raise the expression of the human cathelicidin antimicrobial peptide (CAMP) gene, which is involved in immune function.
  • Probiotics may help create a balanced environment in our digestive tract.
  • Fish oil rich in DHA has been found to enhance B cell activity, which could be promising for those with compromised immune systems.

Nutritional Deficiency – Not Everything we Consume can be Absorbed

According to experts, most people who are 30 years and above suffer from a deteriorating digestive system. Due to their weakening digestive tract, they have problems breaking down the normal food or proteins which means that the nutrients may not be absorbed effectively. In addition, because most people have relatively high levels of stomach acids, most of the nutrients may be destroyed in the process. This means that they may be suffering from nutritional deficiency and yet they are not be aware of it.

It is evident that people who suffer from malnutrition are more susceptible to infection, and there is evidence that deficiencies in certain micronutrients may alter our immune responses.

Research shows that supplements can potentially help to enhance nutritional deficiencies and improve your immunity.

Modulate our Immune System and Build Resilience to COVID-19

While it is important to take preventive measures like wearing a mask, social distancing etc, to reduce the likelihood of getting infected and taking the covid-19 vaccination, it is equally important for us to enhance, regulate our immune system, control inflammation to build resilience to Covid-19 or any other variants of viruses in the long run. Developing a sustainable immune system is the only key to protect you and your family against any potential pandemic in the future.

When there is an infection, our immune system mounts an effective immune response and the infection regresses and helps to promote recovery of healthy tissues in our body. When our immune system is dysfunctional or is in an “imbalance” state , its ability to fight infection reduces significantly and when inflammation is too pronounced, the risk of developing chronic diseases increases. It is a known fact that Immune Dysfunction is the origin of many chronic diseases.

Therefore modulating and regulating our immune system to combat against the Covid-19 is crucial to develop sustainable immunity over time.

How can Caviarlieri, a Swiss Caviar Cellular Therapy supplement help develop sustainable immunity and reduce and control your inflammation?

Sustainable Immunity – Immunomodulating Properties of Caviarlieri

Caviarlieri is formulated with potent bioactive ingredients like Sturgeon Caviar DNA cellular extract and high quality marine peptides and marine collagen peptide which are extremely rich in DHA and EPA (essential fatty acids) known to enhance B cell activity, which can be useful for those with a compromised immune system.

caviarlieri switzeraland - cell therapy caviar food supplement

Manufactured using a proprietary Swiss cold extraction technology, Cellularix in Switzerland, the ingredients on the capsules are kept “active” so that the chemical integrity and potency of the micro nutrients are not destroyed or compromised by our digestive tract. This will help optimize our absorption of the micro nutrients into the body and maximize the outcomes and results.

In addition, the Caviarlieri is made of potent peptides which help to escort the nutrients into our cells for protein synthesis which is an important process to accelerate cellular renewal and repair versus damaged cells. If essential nutrition is provided at the cellular level, it will help to maintain or strengthen the functionality of our immune system and potentially provide cellular immunity.

One of the key ingredient of Caviarlieri is Marine Collagen peptides. These peptides are known to modulate 3 key factors for effective immune response – Inflammation, Tissue Damage, Oxidative Stress. For people with a compromised or dysfunctional immune system, immune modulating is vital.

Most of the fatalities related to Covid-19 are attributed to cytokines storm or hyperinflammation. A key aspect of our immune system is associated with the communication of cells which is mediated by cytokines, a broad category of enzymes or chemical messengers of the cells. Cytokines play a beneficial as well as a detrimental role to our immune response. Apart from triggering inflammation, they are also involved in healthy tissue turnover and they promote the remodeling of ECM (Extra Cellular Matrix). The Extracellular matrix provides support and anchorage for the shape of the cells, regulates and determines cells dynamic and behavior including cell survival, cell proliferation, cell polarity, cell differentiation, cell adhesion, and cell migration.

The goal for a balanced immune health system is therefore to reduce cytokines concentration without blocking its production.

The scientific studies on Caviarlieri published in peer reviewed journals have proven that it has powerful antioxidant properties which can potentially prevent damage to the immune cells by neutralizing free radicals. Free radicals are substances in the environment that can damage cells and reduce immunity. Supplementing with Caviarlieri can also help increase the activation of cells involved in regulating our immunity.

Another active ingredient of Caviarlieri is Selenium. This potent antioxidant keeps our immunity in check by identifying and warding off potentially harmful threats, like viruses, parasites and bacteria. It is also known to help regulate our immune responses and protect us against infectious microorganisms.


Initial Findings Caviarlieri’s effect on TMPRSS2 Receptor – Study On File

TMPRSS2 and Coronaviruses (COVID-19)

TMPRSS2 and Coronaviruses (COVID-19)

Certain viruses, especially coronaviruses including SARS-CoV (that causes SARS), MERS-CoV (causes MERS), and SARS-CoV-2 (which causes COVID19), require TMPRSS2 for their entry into the body. Recent studies have shown that SARS-CoV-2 (in addition to SARS-CoV and MERS-CoV) require ACE2 (the main receptor) as well as TMPRSS2 for entry into epithelial cells.

Both ACE2 and TMPRSS2 are expressed in our nasal, bronchial, and gastrointestinal epithelium. TMPRSS2 activates; or primes, the spike protein domain (a key glycoprotein found on coronaviruses) which leads to the virus fusing to the respiratory epithelia on the cell surface through binding to ACE2. As TMPRSS2 is a serine protease, it primes the spike-domain (S) of SARS-CoV-2 by cleaving as the S1/S2 sites.

In this study, Caviarlieri supplements were given to 5 clinical subjects who are “TMPRSS2-high expressors”. After 30 days of taking Caviarlieri supplements, their TMPRSS2 receptors were quantitated. All of them were found to have significantly reduced expression of the TMPRSS2 receptor that is known for activating the spike of the virus.

One of clinical subjects, who is an orthopaedic physician has shown a significant reduction of the TMPRSS2 levels by 75-fold with Caviarlieri intake and he was Covid-19 Negative even though all members of his family and his collaborators were found positive for Covid-19. Even after repeated molecular tests for Covid-19, this clinical subject was tested and found to be Covid-19 Negative.

This study suggests that Caviarlieri can potentially act protectively against Covid-19 infection by modulating the expression of TMPRSS2 receptor. Further research studies are being conducted to validate the above findings.

Figure: TMPRSS2 gene expression levels of “TMPRSS2-high expressors” before (0 days) and after (30 days) on Caviarlieri. The y axis is in log scale.

TMPRSS2 gene expression levels of

Why is Caviarlieri a safe and potent option?

Caviarlieri is not a drug but an oral food supplement approved by the Swiss Public Health Authority. Unlike drugs or medications, there are no side effects for its long term use. Caviarlieri is also certified by the “Cologne List” to be free of steroids, hormones and stimulants which makes it safe for long-term use.

By providing essential nutrition at the cellular level, Caviarlieri triggers protein synthesis and stimulates our own body system to heal, repair and renew our cells at an accelerated rate against damaged cells. Unlike drugs, it will take a 3-6 months regime for the cellular healing and repair to generate maximum benefits and results.

Caviarlieri is also backed by Science as it has several studies published in peer-reviewed journals and the multifunctional benefits are evidence based claims, like significant increase in energy levels, mood elevation, reduction in joint pain, enhancement of sleep quality, improving brain health, reduction in inflammation and many others. These are important benefits which will potentially protect us from the malefic effects of COVID-19.

Sustainable Immunity

sustainable immunity and healthy lifestyle

Leading a healthy lifestyle is crucial if you desire to have sustainable immunity. Make sure your get enough sleep, exercise regularly, eat a balanced diet and try not to be stressed.

Failing that, vaccination will definitely help improve your immunity. There is however only one caveat. Studies have shown that the antibodies after COVID-19 vaccination will only last for three months, but the upper limit is not yet known because these vaccines have only now been introduced and administered for a few months.